RARA
Retinoic acid receptor alpha
Protein Classes
Protein Summary
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meio ...more
- ENST00000254066
- ENSP00000254066
- ENSG00000131759
- ENST00000394081
- ENSP00000377643
- ENST00000394089
- ENSP00000377649
- ENST00000425707
- ENSP00000389993
- NR1B1
- RAR
- NR1B1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
hub protein | 1 | ||
molecular function | 1 | ||
transcription factor | 0.91 | ||
biological term | 0.89 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 965.32 (req: < 5)
Gene RIFs: 203 (req: <= 3)
Antibodies: 708 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 965.32 (req: >= 5)
Gene RIFs: 203 (req: > 3)
Antibodies: 708 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 85
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 72
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 7
Approved Drugs (7)
1 – 7 of 7
Active Ligands (72)
1 – 10 of 72
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (33)
Reactome (16)
KEGG (5)
PathwayCommons (5)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 16
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of HOX genes during differentiation | ||||
Reactome | Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Reactome | Developmental Biology | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of HOX genes during differentiation | ||||
Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Developmental Biology | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Gene Ontology Terms (95)
Functions (26)
Components (10)
Processes (59)
Items per page:
10
1 – 10 of 26
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Protein-Protein Interactions (254)
1 – 10 of 254
RARG
Family: NR
Novelty: 0.00656363
p_int: 1
Score: 0.985
Data Source: BioPlex,STRINGDB
RARB
Family: NR
Novelty: 0.00294192
p_int: 0.999999931
p_wrong: 6.9e-8
Score: 0.992
Data Source: BioPlex,STRINGDB
RXRB
Family: NR
Novelty: 0.01518662
p_int: 0.952632226
p_ni: 0.000109527
p_wrong: 0.047258247
Score: 0.998
Data Source: BioPlex,STRINGDB
RXRA
Family: NR
Novelty: 0.00314166
Score: 0.998
Data Source: Reactome,STRINGDB
NCOR1
Family: TF
Novelty: 0.00288779
Score: 0.998
Data Source: STRINGDB
NCOA1
Family: Epigenetic
Novelty: 0.00427551
Score: 0.99
Data Source: STRINGDB
NCOR2
Family: TF
Novelty: 0.00127046
Score: 0.989
Data Source: STRINGDB
RXRG
Family: NR
Novelty: 0.02152879
Score: 0.985
Data Source: STRINGDB
EP300
Family: Epigenetic
Novelty: 0.00060382
Score: 0.969
Data Source: STRINGDB
MED1
Family: Enzyme
Novelty: 0.01259825
Score: 0.967
Data Source: STRINGDB
Publication Statistics
PubMed Score 965.32
PubMed score by year
PubTator Score 1447.89
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
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