RARA
Retinoic acid receptor alpha
Protein Summary
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meio ...more
- ENST00000254066
- ENSP00000254066
- ENSG00000131759
- ENST00000394081
- ENSP00000377643
- ENST00000394089
- ENSP00000377649
- ENST00000425707
- ENSP00000389993
- NR1B1
- RAR
- NR1B1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
hub protein | 1 | ||
molecular function | 1 | ||
transcription factor | 0.91 | ||
biological term | 0.89 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1256.63 (req: < 5)
Gene RIFs: 203 (req: <= 3)
Antibodies: 708 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1256.63 (req: >= 5)
Gene RIFs: 203 (req: > 3)
Antibodies: 708 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 85
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 87
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 8
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (8)
Active Ligands (87)
Protein-Protein Interactions (254)
Nearest Tclin Targets
Pathways (33)
Reactome (16)
KEGG (5)
PathwayCommons (5)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of HOX genes during differentiation | ||||
Reactome | Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Reactome | Developmental Biology | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of HOX genes during differentiation | ||||
Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Developmental Biology | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (95)
Functions (26)
Components (10)
Processes (59)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 1 | 1 | 1 | 35 | |||||
body height | 1 | 1 | 1 | 35 | |||||
neutrophil percentage of leukocytes | 1 | 1 | 1 | 29 | |||||
response to cetuximab | 1 | 1 | 0 | 4 | 28.1 | ||||
1 | 1 | 0 | 4 | 28.1 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 1 | 35 | |||||
body height | 1 | 35 | |||||
neutrophil percentage of leukocytes | 1 | 29 | |||||
response to cetuximab | 0 | 4 | 28.1 | ||||
0 | 4 | 28.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | retinoic acid receptor alpha | VGNC:9556 | 454647 | |||||
Mouse | MGI:97856 | 19401 | ||||||
Rat | RGD:3534 | 24705 | ||||||
Dog | retinoic acid receptor alpha | VGNC:45351 | 480526 | |||||
Horse | retinoic acid receptor alpha | VGNC:22184 | 100054274 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | retinoic acid receptor alpha | |||||
Mouse | ||||||
Rat | ||||||
Dog | retinoic acid receptor alpha | |||||
Horse | retinoic acid receptor alpha | |||||
Publication Statistics
PubMed Score 1256.63
PubMed score by year
PubTator Score 1447.89
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (324)
GeneRif Annotations (203)
Items per page:
0 of 0
PMID | Year | Title |
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