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Tclin
RARA
Retinoic acid receptor alpha

Protein Summary
Description
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254066
  • ENSP00000254066
  • ENSG00000131759
  • ENST00000394081
  • ENSP00000377643
  • ENST00000394089
  • ENSP00000377649
  • ENST00000425707
  • ENSP00000389993

Symbol
  • NR1B1
  • RAR
  • NR1B1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
transcription factor
0.91
biological term
0.89


IDG Partner Tools
GlyGen
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1229.44   (req: < 5)
View Publications
Gene RIFs: 203   (req: <= 3)
View Gene RIFs
Antibodies: 708   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1229.44   (req: >= 5)
Gene RIFs: 203   (req: > 3)
Antibodies: 708   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 85
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 72
Explore Active Ligands
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
Explore Approved Drugs
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (33)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
90 targets
R-HSA-5619507
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
90 targets
R-HSA-5617472
Reactome
Developmental Biology
1055 targets
R-HSA-1266738
Reactome
Gene expression (Transcription)
1452 targets
R-HSA-74160
Reactome
Generic Transcription Pathway
1195 targets
R-HSA-212436
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
90 targets
R-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesis
90 targets
R-HSA-5617472
Developmental Biology
1055 targets
R-HSA-1266738
Gene expression (Transcription)
1452 targets
R-HSA-74160
Generic Transcription Pathway
1195 targets
R-HSA-212436
Gene Ontology Terms (95)
Items per page:
10
1 – 10 of 26
GO Term
Evidence
Assigned by
chromatin DNA binding
Inferred from Direct Assay (IDA)
UniProtKB
DNA-binding transcription factor activity
Inferred from Direct Assay (IDA)
UniProtKB
protein heterodimerization activity
Inferred from Direct Assay (IDA)
UniProtKB
protein kinase A binding
Inferred from Direct Assay (IDA)
UniProtKB
retinoic acid binding
Inferred from Direct Assay (IDA)
BHF-UCL
retinoic acid receptor activity
Inferred from Direct Assay (IDA)
BHF-UCL
retinoic acid-responsive element binding
Inferred from Direct Assay (IDA)
UniProtKB
signaling receptor binding
Inferred from Direct Assay (IDA)
UniProtKB
transcription coactivator activity
Inferred from Direct Assay (IDA)
UniProtKB
transcription corepressor activity
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (254)
1 – 10 of 254
RARG
Tclin
Family: NR
Novelty: 0.00667159
p_int: 1
Score: 0.985
Data Source: BioPlex,STRINGDB
RARB
Tclin
Family: NR
Novelty: 0.00257427
p_int: 0.999999931
p_wrong: 6.9e-8
Score: 0.992
Data Source: BioPlex,STRINGDB
RXRB
Tclin
Family: NR
Novelty: 0.01503977
p_int: 0.952632226
p_ni: 0.000109527
p_wrong: 0.047258247
Score: 0.998
Data Source: BioPlex,STRINGDB
RXRA
Tclin
Family: NR
Novelty: 0.00244343
Score: 0.998
Data Source: Reactome,STRINGDB
NCOR1
Tchem
Family: TF
Novelty: 0.0021926
Score: 0.998
Data Source: STRINGDB
NCOA1
Tchem
Family: Epigenetic
Novelty: 0.00344663
Score: 0.99
Data Source: STRINGDB
NCOR2
Tchem
Family: TF
Novelty: 0.00066449
Score: 0.989
Data Source: STRINGDB
RXRG
Tclin
Family: NR
Novelty: 0.01646377
Score: 0.985
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.969
Data Source: STRINGDB
MED1
Tbio
Family: Enzyme
Novelty: 0.00852082
Score: 0.967
Data Source: STRINGDB
Publication Statistics
PubMed Score  1229.44

PubMed score by year
PubTator Score  1447.89

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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