You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MYBL2
Myb-related protein B

Protein Summary
Description
Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217026
  • ENSP00000217026
  • ENSG00000101057
  • ENST00000396863
  • ENSP00000380072

Symbol
  • BMYB
  • BMYB
  • B-MYB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
transcription factor perturbation
0.88
molecular function
0.84
transcription factor binding site profile
0.78
hub protein
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 273.37   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 362   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 273.37   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 362   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
1
2
66
2
2
2
65.3
reticulocyte measurement
2
2
2
61.8
mean corpuscular volume
1
1
1
58.4
mean reticulocyte volume
1
1
1
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
66
2
65.3
reticulocyte measurement
2
61.8
mean corpuscular volume
1
58.4
mean reticulocyte volume
1
46.1
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MYB proto-oncogene like 2
VGNC:10155
458262
Macaque
MYB proto-oncogene like 2
694693
Mouse
MGI:101785
17865
Rat
RGD:1308474
296344
Dog
MYB proto-oncogene like 2
VGNC:43521
477232
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MYB proto-oncogene like 2
Macaque
MYB proto-oncogene like 2
Mouse
Rat
Dog
MYB proto-oncogene like 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P10244-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
G0 and Early G1
Reactome
G2/M Transition
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
G0 and Early G1
G2/M Transition
Gene expression (Transcription)
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (254)
1 – 10 of 254
LIN9
Tbio
Novelty:  0.01112853
p_int:  0.999999995
p_ni:  5e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
LIN37
Tdark
Novelty:  0.27040489
p_int:  0.99999999
p_ni:  7e-9
p_wrong:  2e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
FOXM1
Tbio
Family:  TF
Novelty:  0.00094676
Score:  0.992
Data Source:  Reactome,STRINGDB
CCNB1
Tchem
Novelty:  0.0005503
Score:  0.991
Data Source:  STRINGDB
LIN54
Tbio
Novelty:  0.06173892
Score:  0.989
Data Source:  STRINGDB
RBL1
Tbio
Novelty:  0.00228265
Score:  0.988
Data Source:  STRINGDB
CCNA2
Tchem
Novelty:  0.00049887
Score:  0.984
Data Source:  STRINGDB
CCNB2
Tbio
Novelty:  0.00672914
Score:  0.981
Data Source:  STRINGDB
E2F4
Tbio
Family:  TF
Novelty:  0.00317412
Score:  0.98
Data Source:  STRINGDB
LIN52
Tbio
Novelty:  0.08105335
Score:  0.978
Data Source:  STRINGDB
Publication Statistics
PubMed Score  273.37

PubMed score by year
PubTator Score  141.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: