Tbio MYBL2 Myb-related protein B

Protein Summary

Description

Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• P10244
• B2RBS5
• B7Z8D9
• F8W6N6
• Q53F07
• B-Myb

Gene Name

• MYBL2

Ensembl ID

• ENST00000217026
• ENSP00000217026
• ENSG00000101057
• ENST00000396863
• ENSP00000380072

Symbol

• BMYB
• BMYB
• B-MYB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	1
transcription factor perturbation	0.88
molecular function	0.84
transcription factor binding site profile	0.78
hub protein	0.75

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 273.37   (req: < 5)

Gene RIFs: 51   (req: <= 3)

Antibodies: 362   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 273.37   (req: >= 5)

Gene RIFs: 51   (req: > 3)

Antibodies: 362   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	2	1	2		66
type II diabetes mellitus	EFO_0001360	2	2	2		65.3
reticulocyte measurement	EFO_0010700	2	2	2		61.8
mean corpuscular volume	EFO_0004526	1	1	1		58.4
mean reticulocyte volume	EFO_0010701	1	1	1		46.1

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	2		66
type II diabetes mellitus	EFO_0001360	2		65.3
reticulocyte measurement	EFO_0010700	2		61.8
mean corpuscular volume	EFO_0004526	1		58.4
mean reticulocyte volume	EFO_0010701	1		46.1

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Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	MYB proto-oncogene like 2	VGNC:10155	458262
Macaque	MYB proto-oncogene like 2		694693
Mouse	myeloblastosis oncogene-like 2	MGI:101785	17865
Rat	MYB proto-oncogene like 2	RGD:1308474	296344
Dog	MYB proto-oncogene like 2	VGNC:43521	477232

Species	Name	OMA	EggNOG	Inparanoid
Chimp	MYB proto-oncogene like 2
Macaque	MYB proto-oncogene like 2
Mouse	myeloblastosis oncogene-like 2
Rat	MYB proto-oncogene like 2
Dog	MYB proto-oncogene like 2

Protein Structure (1 Structure, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P10244-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (17)

Reactome (13)

KEGG (1)

PathwayCommons (1)

WikiPathways (2)

Cell Cycle (R-HSA-1640170)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	G0 and Early G1	27 targets	R-HSA-1538133
Reactome	G2/M Transition	184 targets	R-HSA-69275
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160

Name	Explore in Pharos	Explore in Source
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
G0 and Early G1	27 targets	R-HSA-1538133
G2/M Transition	184 targets	R-HSA-69275
Gene expression (Transcription)	1452 targets	R-HSA-74160

Gene Ontology Terms (14)

Functions (4)

Components (2)

Processes (8)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	NTNU_SB
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Direct Assay (IDA)	NTNU_SB
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA-binding transcription factor activity	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (254)

Explore Interacting Targets

1 – 10 of 254

• See Interactions on String-DB

LIN9

Tbio

Novelty:  0.01112853

p_int:  0.999999995

p_ni:  5e-9

Score:  0.998

Data Source:  BioPlex,STRINGDB

LIN37

Tdark

Novelty:  0.27040489

p_int:  0.99999999

p_ni:  7e-9

p_wrong:  2e-9

Score:  0.997

Data Source:  BioPlex,STRINGDB

FOXM1

Tbio

Family:  TF

Novelty:  0.00094676

Score:  0.992

Data Source:  Reactome,STRINGDB

CCNB1

Tchem

Novelty:  0.0005503

Score:  0.991

Data Source:  STRINGDB

LIN54

Tbio

Novelty:  0.06173892

Score:  0.989

Data Source:  STRINGDB

RBL1

Tbio

Novelty:  0.00228265

Score:  0.988

Data Source:  STRINGDB

CCNA2

Tchem

Novelty:  0.00049887

Score:  0.984

Data Source:  STRINGDB

CCNB2

Tbio

Novelty:  0.00672914

Score:  0.981

Data Source:  STRINGDB

E2F4

Tbio

Family:  TF

Novelty:  0.00317412

Score:  0.98

Data Source:  STRINGDB

LIN52

Tbio

Novelty:  0.08105335

Score:  0.978

Data Source:  STRINGDB

Publication Statistics

PubMed Score  273.37

PubMed score by year

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PubTator Score  141.36

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
DNA-binding
Isopeptide bond
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
mean corpuscular volume
mean reticulocyte volume
red blood cell distribution width
reticulocyte count
reticulocyte measurement
type II diabetes mellitus

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
embryo phenotype
hematopoietic system phenotype
immune system phenotype
mortality/aging
neoplasm