MYBL2
Myb-related protein B
Protein Summary
Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
- ENST00000217026
- ENSP00000217026
- ENSG00000101057
- ENST00000396863
- ENSP00000380072
- BMYB
- BMYB
- B-MYB
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 1 | ||
transcription factor perturbation | 0.88 | ||
molecular function | 0.84 | ||
transcription factor binding site profile | 0.78 | ||
hub protein | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 273.37 (req: < 5)
Gene RIFs: 51 (req: <= 3)
Antibodies: 362 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 273.37 (req: >= 5)
Gene RIFs: 51 (req: > 3)
Antibodies: 362 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (254)
LIN9
Novelty: 0.01112853
p_int: 0.999999995
p_ni: 5e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
LIN37
Novelty: 0.27040489
p_int: 0.99999999
p_ni: 7e-9
p_wrong: 2e-9
Score: 0.997
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (17)
Reactome (13)
KEGG (1)
PathwayCommons (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | G0 and Early G1 | ||||
Reactome | G2/M Transition | ||||
Reactome | Gene expression (Transcription) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
G0 and Early G1 | ||||
G2/M Transition | ||||
Gene expression (Transcription) | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (4)
Components (2)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 2 | 1 | 2 | 66 | |||||
2 | 2 | 2 | 65.3 | ||||||
reticulocyte measurement | 2 | 2 | 2 | 61.8 | |||||
mean corpuscular volume | 1 | 1 | 1 | 58.4 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 46.1 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
red blood cell distribution width | 2 | 66 | |||||
2 | 65.3 | ||||||
reticulocyte measurement | 2 | 61.8 | |||||
mean corpuscular volume | 1 | 58.4 | |||||
mean reticulocyte volume | 1 | 46.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | MYB proto-oncogene like 2 | VGNC:10155 | 458262 | |||||
Macaque | MYB proto-oncogene like 2 | 694693 | ||||||
Mouse | MGI:101785 | 17865 | ||||||
Rat | RGD:1308474 | 296344 | ||||||
Dog | MYB proto-oncogene like 2 | VGNC:43521 | 477232 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | MYB proto-oncogene like 2 | |||||
Macaque | MYB proto-oncogene like 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | MYB proto-oncogene like 2 | |||||
Publication Statistics
PubMed Score 273.37
PubMed score by year
PubTator Score 141.36
PubTator score by year
Related Publications
Text Mined References (92)
GeneRif Annotations (51)
Items per page:
0 of 0
PMID | Year | Title |
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