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Tbio
MYBL1
Myb-related protein A

Protein Summary
Description
Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:8058310, PubMed:7987850). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000522677
  • ENSP00000429633
  • ENSG00000185697
  • ENST00000524176
  • ENSP00000428011

Symbol
  • AMYB
  • AMYB
  • A-MYB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
histone modification site profile
0.85
protein domain
0.85
microRNA
0.83
small molecule perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.47   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.47   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
1
1
21.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
21.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MYB proto-oncogene like 1
VGNC:10217
747811
Macaque
MYB proto-oncogene like 1
703351
Mouse
MGI:99925
17864
Rat
RGD:1306940
297783
Dog
MYB proto-oncogene like 1
VGNC:43520
486979
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MYB proto-oncogene like 1
Macaque
MYB proto-oncogene like 1
Mouse
Rat
Dog
MYB proto-oncogene like 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P10243-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Gene Silencing by RNA (R-HSA-211000)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
PIWI-interacting RNA (piRNA) biogenesis
Name
Explore in Pharos
Explore in Source
Gene Silencing by RNA
Gene expression (Transcription)
PIWI-interacting RNA (piRNA) biogenesis
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (106)
1 – 10 of 106
LIN9
Tbio
Novelty:  0.01112853
p_int:  0.999999988
p_ni:  1.2e-8
Score:  0.926
Data Source:  BioPlex,STRINGDB
LIN37
Tdark
Novelty:  0.27040489
p_int:  0.999999903
p_ni:  3.5e-8
p_wrong:  6.3e-8
Score:  0.945
Data Source:  BioPlex,STRINGDB
LIN52
Tbio
Novelty:  0.08105335
p_int:  0.999995648
p_ni:  6.79e-7
p_wrong:  0.000003674
Score:  0.951
Data Source:  BioPlex,STRINGDB
LIN54
Tbio
Novelty:  0.06173892
p_int:  0.999994152
p_ni:  0.000005849
Score:  0.918
Data Source:  BioPlex,STRINGDB
PCBP3
Tbio
Novelty:  0.11681812
p_int:  0.974897658
p_ni:  0.025102339
p_wrong:  3e-9
Data Source:  BioPlex
CREBBP
Tchem
Family:  Epigenetic
Novelty:  0.00111166
Score:  0.851
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.811
Data Source:  STRINGDB
CEBPB
Tbio
Family:  TF
Novelty:  0.00068108
Score:  0.805
Data Source:  STRINGDB
CEBPA
Tbio
Family:  TF
Novelty:  0.00056459
Score:  0.75
Data Source:  STRINGDB
KMT2B
Tbio
Family:  Epigenetic
Novelty:  0.00593529
Score:  0.747
Data Source:  STRINGDB
Publication Statistics
PubMed Score  149.47

PubMed score by year
PubTator Score  48.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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