Tbio MYB Transcriptional activator Myb

Protein Summary

Description

Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• P10242
• E9PI07
• E9PLZ5
• E9PNA4
• E9PNL6
• E9PRS2
• P78391
• P78392
• P78525
• P78526
• Q14023
• Q14024
• Q708E4
• Q708E7
• Q9UE83

Gene Name

• MYB

Ensembl ID

• ENST00000341911
• ENSP00000339992
• ENSG00000118513
• ENST00000367812
• ENSP00000356786
• ENST00000367814
• ENSP00000356788
• ENST00000442647
• ENSP00000410825
• ENST00000525369
• ENSP00000435938
• ENST00000525477
• ENSP00000437081
• ENST00000525514
• ENSP00000435578
• ENST00000528774
• ENSP00000434723
• ENST00000529586
• ENSP00000437264
• ENST00000533384
• ENSP00000432811
• ENST00000533624
• ENSP00000436605
• ENST00000533808
• ENSP00000435293
• ENST00000533837
• ENSP00000434639
• ENST00000534044
• ENSP00000435055
• ENST00000534121
• ENSP00000432851

Symbol

• efg
• Cmyb
• c-myb
• c-myb_CDS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
PubMedID	0.99
gene perturbation	0.98
hub protein	0.97
transcription factor	0.92

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1153.25   (req: < 5)

Gene RIFs: 247   (req: <= 3)

Antibodies: 856   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1153.25   (req: >= 5)

Gene RIFs: 247   (req: > 3)

Antibodies: 856   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0