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Tbio
COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

Protein Summary
Description
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314133
  • ENSP00000321260
  • ENSG00000176340

Symbol
  • COX8
  • COX8L
  • COX
  • COX8
  • VIII
  • COX8L
  • COX8-2
  • VIII-L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
transcription factor perturbation
0.91
transcription factor binding site profile
0.76
co-expressed gene
0.72
virus perturbation
0.72


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.45   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.45   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase subunit 8A (ubiquitous)
742828
Mouse
MGI:105959
12868
Rat
RGD:620638
171335
Dog
cytochrome c oxidase subunit VIIIA (ubiquitous)
476040
Cow
cytochrome c oxidase subunit 8A, mitochondrial
783202
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase subunit 8A (ubiquitous)
Mouse
Rat
Dog
cytochrome c oxidase subunit VIIIA (ubiquitous)
Cow
cytochrome c oxidase subunit 8A, mitochondrial
Pathways (20)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
RNA Polymerase II Transcription
Reactome
Respiratory electron transport
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
RNA Polymerase II Transcription
Respiratory electron transport
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (108)
1 – 10 of 108
COX5B
Tbio
Family: Enzyme
Novelty: 0.01729026
Score: 0.988
Data Source: STRINGDB
COX7C
Tbio
Family: Enzyme
Novelty: 0.05516787
Score: 0.984
Data Source: STRINGDB
COX6B1
Tbio
Family: Enzyme
Novelty: 0.02531055
Score: 0.981
Data Source: STRINGDB
COX6A1
Tbio
Family: Enzyme
Novelty: 0.05543187
Score: 0.977
Data Source: STRINGDB
COX4I1
Tbio
Family: Enzyme
Novelty: 0.00208873
Score: 0.969
Data Source: STRINGDB
COX5A
Tbio
Family: Enzyme
Novelty: 0.02110193
Score: 0.967
Data Source: STRINGDB
COX6C
Tbio
Family: Enzyme
Novelty: 0.04365165
Score: 0.965
Data Source: STRINGDB
COX7B
Tbio
Family: Enzyme
Novelty: 0.09076141
Score: 0.959
Data Source: STRINGDB
NDUFA4
Tclin
Family: Enzyme
Novelty: 0.03103013
Score: 0.957
Data Source: STRINGDB
CYCS
Tchem
Novelty: 0.00014004
Score: 0.947
Data Source: STRINGDB
Publication Statistics
PubMed Score  98.45

PubMed score by year
PubTator Score  13798.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer