Tbio COX8A Cytochrome c oxidase subunit 8A, mitochondrial

Protein Summary

Description

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P10176
• P15955

Gene Name

• COX8A

Ensembl ID

• ENST00000314133
• ENSP00000321260
• ENSG00000176340

Symbol

• COX8
• COX8L
• COX
• COX8
• VIII
• COX8L
• COX8-2
• VIII-L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
transcription factor perturbation	0.91
transcription factor binding site profile	0.76
co-expressed gene	0.72
virus perturbation	0.72

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxidase / Cytochrome C Oxidase Subunit 8a, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxidase / Cytochrome C Oxidase Subunit 8a, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.96   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 67   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.96   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0