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Tbio
CCL3
C-C motif chemokine 3

Protein Summary
Description
Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000613396
  • ENSP00000480753
  • ENSG00000278567
  • ENST00000613922
  • ENSP00000477908
  • ENSG00000277632
  • ENST00000616221
  • ENSP00000483712
  • ENSG00000274221

Symbol
  • G0S19-1
  • MIP1A
  • SCYA3
  • MIP1A
  • SCYA3
  • G0S19-1
  • LD78ALPHA
  • MIP-1-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
0.99
molecular function
0.93
biological term
0.91
disease
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1887.38   (req: < 5)
Gene RIFs: 142   (req: <= 3)
Antibodies: 878   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1887.38   (req: >= 5)
Gene RIFs: 142   (req: > 3)
Antibodies: 878   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 63
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
protein measurement
1
2
2
95
fetal genotype effect measurement
1
2
2
95
protein measurement
1
2
2
95
fetal genotype effect measurement
1
2
2
95
macrophage inflammatory protein 1b measurement
1
3
3
94.9
Items per page:
1 – 5 of 20
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
protein measurement
2
95
fetal genotype effect measurement
2
95
protein measurement
2
95
fetal genotype effect measurement
2
95
macrophage inflammatory protein 1b measurement
3
94.9
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chemokine (C-C motif) ligand 3
454592
Mouse
MGI:98260
20302
Rat
RGD:3647
25542
Horse
chemokine (C-C motif) ligand 3
100057909
Cow
chemokine (C-C motif) ligand 3
282170
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chemokine (C-C motif) ligand 3
Mouse
Rat
Horse
chemokine (C-C motif) ligand 3
Cow
chemokine (C-C motif) ligand 3
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P10147-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-10 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-10 signaling
Signaling by Interleukins
Gene Ontology Terms (68)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (210)
1 – 10 of 210
CCR5
Tclin
Family:  GPCR
Novelty:  0.00022549
Score:  0.986
Data Source:  STRINGDB
CCL4
Tbio
Novelty:  0.00069278
Score:  0.983
Data Source:  STRINGDB
IL10
Tbio
Novelty:  0.00004352
Score:  0.982
Data Source:  STRINGDB
CCR1
Tchem
Family:  GPCR
Novelty:  0.00218065
Score:  0.977
Data Source:  STRINGDB
CCL3L1
Tbio
Novelty:  0.01124082
Score:  0.952
Data Source:  STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.946
Data Source:  STRINGDB
IL1B
Tclin
Novelty:  0.0000308
Score:  0.945
Data Source:  STRINGDB
CXCR2
Tchem
Family:  GPCR
Novelty:  0.00108314
Score:  0.923
Data Source:  STRINGDB
IL6
Tclin
Novelty:  0.00001819
Score:  0.916
Data Source:  STRINGDB
CCR3
Tchem
Family:  GPCR
Novelty:  0.00197059
Score:  0.916
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1887.38

PubMed score by year
PubTator Score  907.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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