CXCL8
Interleukin-8
Protein Summary
IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene c ...more
- ENST00000307407
- ENSP00000306512
- ENSG00000169429
- IL8
- IL8
- NAF
- GCP1
- LECT
- LUCT
- NAP1
- GCP-1
- LYNAP
- MDNCF
- MONAP
- NAP-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
chemical | 1 | ||
gene perturbation | 1 | ||
PubMedID | 1 | ||
biological process | 0.99 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19346.63 (req: < 5)
Gene RIFs: 2155 (req: <= 3)
Antibodies: 1509 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19346.63 (req: >= 5)
Gene RIFs: 2155 (req: > 3)
Antibodies: 1509 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 35
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 17
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4