Tchem CXCL8 Interleukin-8

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Chemokine / Interleukin-8

DTO Classes

Protein / Signaling / Chemokine / Interleukin-8

Protein Summary

Description

IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• P10145
• B2R4L8
• Q6FGF6
• Q6LAE6
• Q96RG6
• Q9C077
• Q9UCE1
• Q9UCR8
• Q9UCR9
• Q9UCS0
• IL-8

Gene Name

• CXCL8

Ensembl ID

• ENST00000307407
• ENSP00000306512
• ENSG00000169429

Symbol

• IL8
• IL8
• NAF
• GCP1
• LECT
• LUCT
• NAP1
• GCP-1
• LYNAP
• MDNCF
• MONAP
• NAP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
chemical	1
gene perturbation	1
PubMedID	1
biological process	0.99

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17118.32   (req: < 5)

Gene RIFs: 1814   (req: <= 3)

Antibodies: 1509   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17118.32   (req: >= 5)

Gene RIFs: 1814   (req: > 3)

Antibodies: 1509   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4

Approved Drugs (4)

Explore Approved Drugs

1 – 4 of 4

indomethacin

CXCL8Tchem

IC50 : 7.3

diclofenac

CXCL8Tchem

IC50 : 8.1

ibuprofen

CXCL8Tchem

IC50 : 7.30000019

tolmetin

CXCL8Tchem

IC50 : 7.05

Active Ligands (17)

Explore Active Ligands

1 – 10 of 17

Noditinib-1

CXCL8Tchem

IC50 : 6.26

2-(2-(2-fluorophenylamino)phenyl)acetic acid

CXCL8Tchem

IC50 : 8.05

2-{2-[(2,6-Dichlorophenyl)amino]phenyl}propanoic acid

CXCL8Tchem

IC50 : 8

2-{2-[(2,6-Dichlorophenyl)amino]phenyl}propanamide

CXCL8Tchem

IC50 : 7.92

CHEMBL549974

CXCL8Tchem

IC50 : 7.89

2-(2-(2-fluorophenoxy)phenyl)acetic acid

CXCL8Tchem

IC50 : 7.89

CHEMBL552258

CXCL8Tchem

IC50 : 7.7

(R)-2-(3-benzoylphenyl)propanoic acid

CXCL8Tchem

IC50 : 7.7

CHEMBL569366

CXCL8Tchem

IC50 : 7.6

2-(2-(2,5-dichlorophenylamino)phenyl)acetic acid

CXCL8Tchem

IC50 : 7.6

GWAS Traits (28)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	2	3	3		96.4
neutrophil percentage of leukocytes	EFO_0007990	2	3	3		95.8
lymphocyte percentage of leukocytes	EFO_0007993	2	3	3		94.9
C-X-C motif chemokine 6 measurement	EFO_0008059	1	1	1		88.7
leukocyte count	EFO_0004308	2	1	2		86.1

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	3		96.4
neutrophil percentage of leukocytes	EFO_0007990	3		95.8
lymphocyte percentage of leukocytes	EFO_0007993	3		94.9
C-X-C motif chemokine 6 measurement	EFO_0008059	1		88.7
leukocyte count	EFO_0004308	2		86.1

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Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	C-X-C motif chemokine ligand 8	VGNC:8664	471205
Dog	C-X-C motif chemokine ligand 8	VGNC:39749	403850
Horse	C-X-C motif chemokine ligand 8	VGNC:49474	100037400
Cow	C-X-C motif chemokine ligand 8	VGNC:27853	280828
Pig	C-X-C motif chemokine ligand 8		396880

Species	Name	OMA	EggNOG	Inparanoid
Chimp	C-X-C motif chemokine ligand 8
Dog	C-X-C motif chemokine ligand 8
Horse	C-X-C motif chemokine ligand 8
Cow	C-X-C motif chemokine ligand 8
Pig	C-X-C motif chemokine ligand 8

Protein Structure (13 Structures, 1 AlphaFold Model)

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Representation

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  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

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More information can be found at RCSB PDB

AF-P10145-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 13

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (97)

Reactome (21)

KEGG (29)

PathwayCommons (22)

WikiPathways (25)

ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ATF4 activates genes in response to endoplasmic reticulum stress	27 targets	R-HSA-380994
Reactome	Cellular Senescence	164 targets	R-HSA-2559583
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Cellular responses to stress	392 targets	R-HSA-2262752
Reactome	Chemokine receptors bind chemokines	48 targets	R-HSA-380108

Name	Explore in Pharos	Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress	27 targets	R-HSA-380994
Cellular Senescence	164 targets	R-HSA-2559583
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Cellular responses to stress	392 targets	R-HSA-2262752
Chemokine receptors bind chemokines	48 targets	R-HSA-380108

Gene Ontology Terms (37)

Functions (2)

Components (2)

Processes (33)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
chemokine activity	Inferred from Direct Assay (IDA)	UniProtKB
interleukin-8 receptor binding	Inferred from Physical Interaction (IPI)	UniProtKB

Protein-Protein Interactions (877)

Explore Interacting Targets

1 – 10 of 877

• See Interactions on String-DB

PSMD10

Tbio

Family:  Enzyme

Novelty:  0.01331382

p_int:  0.773525832

p_ni:  0.226474168

Data Source:  BioPlex

CXCR2

Tchem

Family:  GPCR

Novelty:  0.00108314

Score:  0.997

Data Source:  STRINGDB

CXCR1

Tchem

Family:  GPCR

Novelty:  0.00224501

Score:  0.996

Data Source:  Reactome,STRINGDB

IL10

Tbio

Novelty:  0.00004352

Score:  0.996

Data Source:  STRINGDB

CCL5

Tchem

Novelty:  0.00032607

Score:  0.993

Data Source:  STRINGDB

IL1B

Tclin

Novelty:  0.0000308

Score:  0.992

Data Source:  STRINGDB

IL4

Tbio

Novelty:  0.00005852

Score:  0.992

Data Source:  STRINGDB

CCL4

Tbio

Novelty:  0.00069278

Score:  0.991

Data Source:  STRINGDB

CCL20

Tbio

Novelty:  0.00158263

Score:  0.988

Data Source:  STRINGDB

CXCL10

Tbio

Novelty:  0.00040194

Score:  0.987

Data Source:  STRINGDB

Publication Statistics

PubMed Score  17118.32

PubMed score by year

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PubTator Score  12509.97

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Chemotaxis
Citrullination
Complete proteome
Cytokine
Direct protein sequencing
Disulfide bond
Inflammatory response
Reference proteome
Secreted

GWAS Trait Find Similar Targets

No Header	No Header
basophil percentage of granulocytes
basophil percentage of leukocytes
blood protein measurement
C-X-C motif chemokine 6 measurement
coronary artery disease
CXCL6 measurement
eosinophil percentage of leukocytes
esterified cholesterol measurement
fetal genotype effect measurement
free cholesterol measurement