Protein Summary
IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene c ...more
- ENST00000307407
- ENSP00000306512
- ENSG00000169429
- IL8
- IL8
- NAF
- GCP1
- LECT
- LUCT
- NAP1
- GCP-1
- LYNAP
- MDNCF
- MONAP
- NAP-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
chemical | 1 | ||
gene perturbation | 1 | ||
PubMedID | 1 | ||
biological process | 0.99 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17118.32 (req: < 5)
Gene RIFs: 1814 (req: <= 3)
Antibodies: 1509 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17118.32 (req: >= 5)
Gene RIFs: 1814 (req: > 3)
Antibodies: 1509 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 35
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 17
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (4)
Active Ligands (17)
Protein-Protein Interactions (877)
PSMD10
Family: Enzyme
Novelty: 0.01331382
p_int: 0.773525832
p_ni: 0.226474168
Data Source: BioPlex
Nearest Tclin Targets (9)
Upstream (6)
Downstream (3)
1 – 5 of 6
Pathways (97)
Reactome (21)
KEGG (29)
PathwayCommons (22)
WikiPathways (25)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | ATF4 activates genes in response to endoplasmic reticulum stress | ||||
Reactome | Cellular Senescence | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Chemokine receptors bind chemokines | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
ATF4 activates genes in response to endoplasmic reticulum stress | ||||
Cellular Senescence | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Chemokine receptors bind chemokines | ||||
Viral Interactions (0)
Gene Ontology Terms (37)
Functions (2)
Components (2)
Processes (33)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations ()
GWAS Traits (28)
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neutrophil count | 2 | 3 | 3 | 96.4 | |||||
neutrophil percentage of leukocytes | 2 | 3 | 3 | 95.8 | |||||
lymphocyte percentage of leukocytes | 2 | 3 | 3 | 94.9 | |||||
C-X-C motif chemokine 6 measurement | 1 | 1 | 1 | 88.7 | |||||
leukocyte count | 2 | 1 | 2 | 86.1 | |||||
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neutrophil count | 3 | 96.4 | |||||
neutrophil percentage of leukocytes | 3 | 95.8 | |||||
lymphocyte percentage of leukocytes | 3 | 94.9 | |||||
C-X-C motif chemokine 6 measurement | 1 | 88.7 | |||||
leukocyte count | 2 | 86.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | C-X-C motif chemokine ligand 8 | VGNC:8664 | 471205 | |||||
Dog | C-X-C motif chemokine ligand 8 | VGNC:39749 | 403850 | |||||
Horse | C-X-C motif chemokine ligand 8 | VGNC:49474 | 100037400 | |||||
Cow | C-X-C motif chemokine ligand 8 | VGNC:27853 | 280828 | |||||
Pig | C-X-C motif chemokine ligand 8 | 396880 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | C-X-C motif chemokine ligand 8 | |||||
Dog | C-X-C motif chemokine ligand 8 | |||||
Horse | C-X-C motif chemokine ligand 8 | |||||
Cow | C-X-C motif chemokine ligand 8 | |||||
Pig | C-X-C motif chemokine ligand 8 | |||||
Publication Statistics
PubMed Score 17118.32
PubMed score by year
PubTator Score 12509.97
PubTator score by year
Related Publications
Text Mined References (2064)
GeneRif Annotations (1814)
Items per page:
0 of 0
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