Protein Classes
Protein Summary
IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene c ...more
- ENST00000307407
- ENSP00000306512
- ENSG00000169429
- IL8
- IL8
- NAF
- GCP1
- LECT
- LUCT
- NAP1
- GCP-1
- LYNAP
- MDNCF
- MONAP
- NAP-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
chemical | 1 | ||
gene perturbation | 1 | ||
PubMedID | 1 | ||
biological process | 0.99 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10650.31 (req: < 5)
Gene RIFs: 1814 (req: <= 3)
Antibodies: 1509 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10650.31 (req: >= 5)
Gene RIFs: 1814 (req: > 3)
Antibodies: 1509 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 35
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 16
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4
Approved Drugs (4)
1 – 4 of 4
Active Ligands (16)
1 – 10 of 16
Protein Data Bank (13)
1 – 5 of 13
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (97)
Reactome (21)
KEGG (29)
PathwayCommons (22)
WikiPathways (25)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 21
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | ATF4 activates genes in response to endoplasmic reticulum stress | ||||
Reactome | Cellular Senescence | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Chemokine receptors bind chemokines | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
ATF4 activates genes in response to endoplasmic reticulum stress | ||||
Cellular Senescence | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Chemokine receptors bind chemokines | ||||
Gene Ontology Terms (37)
Functions (2)
Components (2)
Processes (33)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Protein-Protein Interactions (877)
1 – 10 of 877
PSMD10
Family: Enzyme
Novelty: 0.01419544
p_int: 0.773525832
p_ni: 0.226474168
Data Source: BioPlex
CXCR2
Family: GPCR
Novelty: 0.00123769
Score: 0.997
Data Source: STRINGDB
CXCR1
Family: GPCR
Novelty: 0.00285279
Score: 0.996
Data Source: Reactome,STRINGDB
IL10
Novelty: 0.00007359
Score: 0.996
Data Source: STRINGDB
CCL5
Novelty: 0.00039604
Score: 0.993
Data Source: STRINGDB
IL1B
Novelty: 0.00003644
Score: 0.992
Data Source: STRINGDB
IL4
Novelty: 0.00010156
Score: 0.992
Data Source: STRINGDB
CCL4
Novelty: 0.00091965
Score: 0.991
Data Source: STRINGDB
CCL20
Novelty: 0.00082571
Score: 0.988
Data Source: STRINGDB
CXCL10
Novelty: 0.00051044
Score: 0.987
Data Source: STRINGDB
Publication Statistics
PubMed Score 10650.31
PubMed score by year
PubTator Score 12509.97
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by:
UniProt Keyword
GWAS Trait