Tchem GZMB Granzyme B

Protein Summary

Description

This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• P10144
• Q8N1D2
• Q9UCC1

Gene Name

• GZMB

Ensembl ID

• ENST00000216341
• ENSP00000216341
• ENSG00000100453

Symbol

• CGL1
• CSPB
• CTLA1
• GRB
• C11
• HLP
• CCPI
• CGL1
• CSPB
• SECT
• CGL-1
• CSP-B
• CTLA1
• CTSGL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.98
cellular component	0.63
hub protein	0.63
biological process	0.6
disease	0.6

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Granzyme B

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Granzyme B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2371.27   (req: < 5)

Gene RIFs: 261   (req: <= 3)

Antibodies: 1010   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2371.27   (req: >= 5)

Gene RIFs: 261   (req: > 3)

Antibodies: 1010   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0