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Tbio
SRGN
Serglycin

Protein Summary
Description
Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization. This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242465
  • ENSP00000242465
  • ENSG00000122862

Symbol
  • PRG
  • PRG1
  • PPG
  • PRG
  • PRG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.98
transcription factor perturbation
0.96
kinase perturbation
0.84
cellular component
0.81
disease
0.79


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.04   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.04   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serglycin
VGNC:5789
450503
Mouse
MGI:97756
19073
Rat
RGD:619969
56782
Dog
serglycin
VGNC:46803
609421
Horse
serglycin
VGNC:23583
100063248
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serglycin
Mouse
Rat
Dog
serglycin
Horse
serglycin
Pathways (5)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Protein-Protein Interactions (146)
1 – 10 of 146
PF4
Tbio
Novelty: 0.00038481
Score: 0.956
Data Source: STRINGDB
ALB
Tchem
Novelty: 0.00000616
Score: 0.946
Data Source: STRINGDB
SERPINE1
Tchem
Novelty: 0.00017629
Score: 0.94
Data Source: STRINGDB
TGFB2
Tbio
Novelty: 0.00050804
Score: 0.94
Data Source: STRINGDB
FERMT3
Tbio
Novelty: 0.01172918
Score: 0.934
Data Source: STRINGDB
PPBP
Tbio
Novelty: 0.00048307
Score: 0.929
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.926
Data Source: STRINGDB
MMRN1
Tbio
Novelty: 0.03378128
Score: 0.926
Data Source: STRINGDB
F13A1
Tchem
Family: Enzyme
Novelty: 0.00629746
Score: 0.924
Data Source: STRINGDB
HGF
Tchem
Family: Enzyme
Novelty: 0.00035574
Score: 0.921
Data Source: STRINGDB
Publication Statistics
PubMed Score  190.04

PubMed score by year
PubTator Score  407.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer