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Tbio
FDX1
Adrenodoxin, mitochondrial

Protein Summary
Description
Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783). Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783). Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage (PubMed:20547883, PubMed:21636783). Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to mitochondrial cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism. Pseudogenes of this functional gene are found on chromosomes 20 and 21. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260270
  • ENSP00000260270
  • ENSG00000137714

Symbol
  • ADX
  • ADX
  • FDX
  • LOH11CR1D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
pathway
0.91
transcription factor perturbation
0.91
virus perturbation
0.85
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 813.43   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 813.43   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
2.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
2.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ferredoxin 1
VGNC:3279
451689
Mouse
MGI:103224
14148
Rat
RGD:62036
29189
Dog
ferredoxin 1
VGNC:40813
100686950
Horse
ferredoxin 1
VGNC:17984
100630891
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ferredoxin 1
Mouse
Rat
Dog
ferredoxin 1
Horse
ferredoxin 1
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P10109-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Reactome
Disease
Reactome
Diseases of metabolism
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytochrome P450 - arranged by substrate type
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Disease
Diseases of metabolism
Protein-Protein Interactions (92)
1 – 10 of 92
FDXR
Tbio
Family: Enzyme
Novelty: 0.00171588
Score: 0.999
Data Source: Reactome,STRINGDB
CYP11A1
Tclin
Family: Enzyme
Novelty: 0.00096368
Score: 0.998
Data Source: Reactome,STRINGDB
FXN
Tbio
Novelty: 0.00084064
Score: 0.978
Data Source: STRINGDB
LYRM4
Tbio
Novelty: 0.03319832
Score: 0.977
Data Source: STRINGDB
STAR
Tbio
Novelty: 0.0012662
Score: 0.97
Data Source: STRINGDB
ISCU
Tbio
Novelty: 0.0043097
Score: 0.956
Data Source: STRINGDB
FDX2
Tdark
Novelty: 0.05747769
Score: 0.949
Data Source: Reactome,STRINGDB
HSCB
Tbio
Novelty: 0.01330125
Score: 0.926
Data Source: STRINGDB
NFS1
Tbio
Family: Enzyme
Novelty: 0.01274706
Score: 0.885
Data Source: STRINGDB
ISCA1
Tbio
Novelty: 0.01288069
Score: 0.842
Data Source: STRINGDB
Publication Statistics
PubMed Score  813.43

PubMed score by year
PubTator Score  40.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer