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Tbio
PYY
Peptide YY

Protein Summary
Description
This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility. This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360085
  • ENSP00000353198
  • ENSG00000131096
  • ENST00000592796
  • ENSP00000467310

Symbol
  • PYY1
  • PYY-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.8
PubMedID
0.64
disease
0.59
gene perturbation
0.56
transcription factor perturbation
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1726.98   (req: < 5)
Gene RIFs: 97   (req: <= 3)
Antibodies: 427   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1726.98   (req: >= 5)
Gene RIFs: 97   (req: > 3)
Antibodies: 427   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (305)
USP25
Tchem
Family:  Enzyme
Novelty:  0.03671706
p_int:  0.997299766
p_ni:  0.002700179
p_wrong:  5.5e-8
Data Source:  BioPlex
XPNPEP3
Tbio
Family:  Enzyme
Novelty:  0.02209842
p_int:  0.975314727
p_ni:  0.024685273
Data Source:  BioPlex
BTBD1
Tbio
Novelty:  0.19772296
p_int:  0.876733668
p_ni:  0.123261075
p_wrong:  0.000005257
Data Source:  BioPlex
GLRX
Tbio
Novelty:  0.00111903
p_int:  0.86261421
p_ni:  0.109878658
p_wrong:  0.027507131
Data Source:  BioPlex
PLXDC2
Tbio
Novelty:  0.06496695
p_int:  0.817284914
p_ni:  0.18271494
p_wrong:  1.46e-7
Data Source:  BioPlex
NPY2R
Tchem
Family:  GPCR
Novelty:  0.01177255
Score:  0.99
Data Source:  Reactome,STRINGDB
NPY1R
Tchem
Family:  GPCR
Novelty:  0.00438376
Score:  0.989
Data Source:  Reactome,STRINGDB
SST
Tbio
Novelty:  0.00005944
Score:  0.971
Data Source:  STRINGDB
NPY4R
Tchem
Family:  GPCR
Novelty:  0.11465741
Score:  0.971
Data Source:  Reactome,STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.968
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (589)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
6
96.8
triglyceride measurement
2
2
2
69.7
sex hormone-binding globulin measurement
4
2
4
55.2
urate measurement
1
1
1
53.7
bone density
1
2
2
40.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
96.8
triglyceride measurement
2
69.7
sex hormone-binding globulin measurement
4
55.2
urate measurement
1
53.7
bone density
2
40.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptide YY
VGNC:14186
468391
Macaque
peptide YY
714041
Mouse
MGI:99924
217212
Rat
RGD:1593289
287730
Dog
peptide YY
607156
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptide YY
Macaque
peptide YY
Mouse
Rat
Dog
peptide YY
Publication Statistics
PubMed Score 1726.98
PubMed score by year
PubTator Score 736.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title