Tdark GLI4 Zinc finger protein GLI4

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Zinc Finger Protein Gli4

Protein / ... / Krab Box Transcription Factor / Zinc Finger Protein Gli4

Protein Summary

Uniprot Accession IDs

• P10075
• Q96CK9

Gene Name

• GLI4

Ensembl ID

• ENST00000340042
• ENSP00000345024
• ENSG00000250571
• ENST00000523522
• ENSP00000430987

Symbol

• HKR4
• HKR4
• ZNF928

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.68
tissue sample	0.57
transcription factor	0.52
cell line	0.51
tissue	0.48

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.82   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 170   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.82   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (1)

WikiPathways (1)

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	Tumor suppressor activity of SMARCB1	61 targets	WP4204_r105455

Name	Explore in Pharos	Explore in Source
Tumor suppressor activity of SMARCB1	61 targets	WP4204_r105455

Gene Ontology Terms (6)

Functions (4)

Components (1)

Processes (1)

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA-binding transcription factor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (15)

Explore Interacting Targets

1 – 10 of 15

• See Interactions on String-DB

VTN

Tbio

Family: TF

Novelty: 0.00057817

p_int: 0.999998906

p_ni: 1.5e-8

p_wrong: 0.000001079

Score: 0.229

Data Source: BioPlex,STRINGDB

RETN

Tbio

Novelty: 0.00076494

p_int: 0.999994028

p_ni: 7.07e-7

p_wrong: 0.000005265

Score: 0.359

Data Source: BioPlex,STRINGDB

LRRC14

Tdark

Novelty: 1.125

Score: 0.585

Data Source: STRINGDB

NRAS

Tchem

Family: Enzyme

Novelty: 0.00085585

Score: 0.521

Data Source: STRINGDB

LRRC24

Tdark

Novelty: 9

Score: 0.505

Data Source: STRINGDB

WDR97

Tdark

Score: 0.491

Data Source: STRINGDB

STK36

Tdark

Family: Kinase

Novelty: 0.30550841

Score: 0.478

Data Source: STRINGDB

DXO

Tbio

Family: Enzyme

Novelty: 0.01961014

Score: 0.473

Data Source: STRINGDB

MYCL

Tbio

Family: TF

Novelty: 0.00183456

Score: 0.469

Data Source: STRINGDB

MMTAG2

Tdark

Novelty: 0.75

Score: 0.457

Data Source: STRINGDB

Publication Statistics

PubMed Score  1.82

PubMed score by year

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PubTator Score  2.17

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MAALGDIQESPSVPSPVSLSSPGTPGTQHHEPQLHLHGHQHGSPGSSPKVLSQPSDLDLQDVEEVEIGRD

1-70

TFWPDSEPKPEQAPRSPGSQAPDEGAGGALRSLLRSLPRRARCSAGFGPESSAERPAGQPPGAVPCAQPR

70-140

GAWRVTLVQQAAAGPEGAPERAAELGVNFGRSRQGSARGAKPHRCEACGKSFKYNSLLLKHQRIHTGEKP

140-210

YACHECGKRFRGWSGFIQHHRIHTGEKPYECGQCGRAFSHSSHFTQHLRIHNGEKPYKCGECGQAFSQSS

210-280

NLVRHQRLHTGEKPYACSQCGKAFIWSSVLIEHQRIHTGEKPYECSDCGKAFRGRSHFFRHLRTHTGEKP

280-350

FACGACGKAFGQSSQLIQHQRVHYRE

350-376

MAALGDIQESPSVPSPVSLSSPGTPGTQHHEPQLHLHGHQHGSPGSSPKVLSQPSDLDLQDVEEVEIGRDTFWPDSEPKPEQAPRSPGSQAPDEGAGGALRSLLRSLPRRARCSAGFGPESSAERPAGQPPGAVPCAQPRGAWRVTLVQQAAAGPEGAPERAAELGVNFGRSRQGSARGAKPHRCEACGKSFKYNSLLLKHQRIHTGEKPYACHECGKRFRGWSGFIQHHRIHTGEKPYECGQCGRAFSHSSHFTQHLRIHNGEKPYKCGECGQAFSQSSNLVRHQRLHTGEKPYACSQCGKAFIWSSVLIEHQRIHTGEKPYECSDCGKAFRGRSHFFRHLRTHTGEKPFACGACGKAFGQSSQLIQHQRVHYRE

Find similar targets by:

Uniprot Keyword

Complete proteome
DNA-binding
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Zinc
Zinc-finger