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Tbio
ZBTB48
Telomere zinc finger-associated protein

Protein Summary
Description
Telomere-binding protein that acts as a regulator of telomere length (PubMed:28500257, PubMed:28082411). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891, PubMed:28500257). Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257). Regulates expression the J and/or S elements in MHC II promoter (PubMed:7969177). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377674
  • ENSP00000366902
  • ENSG00000204859

Symbol
  • HKR3
  • TZAP
  • ZNF855
  • HKR3
  • TZAP
  • ZNF855
  • pp9964
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
histone modification site profile
0.79
kinase perturbation
0.71
tissue sample
0.7
small molecule perturbation
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.53   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.53   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (107)
HIST1H1C
Tbio
Novelty:  0.00415337
p_int:  0.999709084
p_ni:  0.000290916
Data Source:  BioPlex
NSD1
Tbio
Family:  Epigenetic
Novelty:  0.00495576
p_int:  0.999638733
p_ni:  0.000361267
Score:  0.281
Data Source:  BioPlex,STRINGDB
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.99849229
p_ni:  0.001507697
p_wrong:  1.3e-8
Score:  0.186
Data Source:  BioPlex,STRINGDB
ZNF121
Tdark
Family:  TF
Novelty:  0.233609
p_int:  0.996954306
p_ni:  0.002892987
p_wrong:  0.000152707
Data Source:  BioPlex
ZC3HAV1
Tbio
Novelty:  0.01357759
p_int:  0.996224394
p_ni:  0.003775606
Score:  0.22
Data Source:  BioPlex,STRINGDB
MRPS25
Tdark
Novelty:  0.59354314
p_int:  0.996161038
p_ni:  0.003779323
p_wrong:  0.000059639
Data Source:  BioPlex
MRPS34
Tbio
Novelty:  0.29355603
p_int:  0.996066513
p_ni:  0.003933487
Score:  0.306
Data Source:  BioPlex,STRINGDB
RRP7A
Tbio
Novelty:  0.11315285
p_int:  0.995565528
p_ni:  0.004434472
Data Source:  BioPlex
MRPS35
Tdark
Novelty:  6.44240335
p_int:  0.991007541
p_ni:  0.008992459
Data Source:  BioPlex
FBXO11
Tbio
Novelty:  0.02762674
p_int:  0.990438421
p_ni:  0.009561578
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
87.6
2
2
2
83.6
FEV/FEC ratio
1
1
1
75.3
mean corpuscular volume
1
1
1
69
comparative body size at age 10, self-reported
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
87.6
2
83.6
FEV/FEC ratio
1
75.3
mean corpuscular volume
1
69
comparative body size at age 10, self-reported
1
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger and BTB domain containing 48
VGNC:8126
457899
Macaque
zinc finger and BTB domain containing 48
704628
Mouse
MGI:2140248
100090
Rat
RGD:1311581
362668
Dog
zinc finger and BTB domain containing 48
VGNC:48540
608070
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger and BTB domain containing 48
Macaque
zinc finger and BTB domain containing 48
Mouse
Rat
Dog
zinc finger and BTB domain containing 48
Publication Statistics
PubMed Score 17.53
PubMed score by year
PubTator Score 4.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title