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Tbio
GLI3
Transcriptional activator GLI3

Protein Summary
Description
Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. T ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395925
  • ENSP00000379258
  • ENSG00000106571

Symbol
  • PHS
  • ACLS
  • GCPS
  • PAPA
  • PAPB
  • PAP-A
  • PAPA1
  • PPDIV
  • GLI3FL
  • GLI3-190
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.95
trait
0.93
phenotype
0.84
virus perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1511.02   (req: < 5)
Gene RIFs: 83   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1511.02   (req: >= 5)
Gene RIFs: 83   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 75
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (35)
GLI proteins bind promoters of Hh responsive genes to promote transcription (R-HSA-5635851)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GLI proteins bind promoters of Hh responsive genes to promote transcription
Reactome
GLI3 is processed to GLI3R by the proteasome
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Hedgehog 'off' state
Name
Explore in Pharos
Explore in Source
GLI proteins bind promoters of Hh responsive genes to promote transcription
GLI3 is processed to GLI3R by the proteasome
Gene expression (Transcription)
Generic Transcription Pathway
Hedgehog 'off' state
Gene Ontology Terms (85)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred by Curator (IC)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (273)
1 – 10 of 273
CELA1
Tchem
Family: Enzyme
Novelty: 0.00355186
p_int: 0.990796747
p_ni: 0.007986881
p_wrong: 0.001216372
Score: 0.235
Data Source: BioPlex,STRINGDB
THSD4
Tbio
Novelty: 0.16828393
p_int: 0.947541428
p_ni: 0.001430585
p_wrong: 0.051027988
Score: 0.27
Data Source: BioPlex,STRINGDB
RCCD1
Tbio
Novelty: 0.10479042
p_int: 0.755965161
p_ni: 0.000903868
p_wrong: 0.243130971
Score: 0.28
Data Source: BioPlex,STRINGDB
SUFU
Tbio
Novelty: 0.00485324
Score: 0.997
Data Source: Reactome,STRINGDB
PTCH1
Tbio
Novelty: 0.00096312
Score: 0.99
Data Source: STRINGDB
SMO
Tclin
Family: GPCR
Novelty: 0.04792829
Score: 0.984
Data Source: STRINGDB
SPOP
Tbio
Novelty: 0.00958399
Score: 0.977
Data Source: Reactome,STRINGDB
BTRC
Tbio
Novelty: 0.00393331
Score: 0.972
Data Source: STRINGDB
PTCH2
Tbio
Novelty: 0.01422381
Score: 0.965
Data Source: STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00083441
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  1511.02

PubMed score by year
PubTator Score  259.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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