You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GLI3
Transcriptional activator GLI3

Protein Summary
Description
Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. T ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395925
  • ENSP00000379258
  • ENSG00000106571

Symbol
  • PHS
  • ACLS
  • GCPS
  • PAPA
  • PAPB
  • PAP-A
  • PAPA1
  • PPDIV
  • GLI3FL
  • GLI3-190
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.95
trait
0.93
phenotype
0.84
virus perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1677.86   (req: < 5)
Gene RIFs: 83   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1677.86   (req: >= 5)
Gene RIFs: 83   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 75
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
56.6
alkaline phosphatase measurement
1
1
1
50.6
hip circumference
1
1
1
50.6
self reported educational attainment
1
1
1
46.9
nose morphology measurement
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
56.6
alkaline phosphatase measurement
1
50.6
hip circumference
1
50.6
self reported educational attainment
1
46.9
nose morphology measurement
1
38.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GLI family zinc finger 3
VGNC:4376
463369
Macaque
GLI family zinc finger 3
702494
Mouse
MGI:95729
14634
Rat
RGD:620272
140588
Dog
GLI family zinc finger 3
VGNC:41258
483244
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GLI family zinc finger 3
Macaque
GLI family zinc finger 3
Mouse
Rat
Dog
GLI family zinc finger 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P10071-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (35)
GLI proteins bind promoters of Hh responsive genes to promote transcription (R-HSA-5635851)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GLI proteins bind promoters of Hh responsive genes to promote transcription
Reactome
GLI3 is processed to GLI3R by the proteasome
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Hedgehog 'off' state
Name
Explore in Pharos
Explore in Source
GLI proteins bind promoters of Hh responsive genes to promote transcription
GLI3 is processed to GLI3R by the proteasome
Gene expression (Transcription)
Generic Transcription Pathway
Hedgehog 'off' state
Gene Ontology Terms (85)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred by Curator (IC)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (273)
1 – 10 of 273
CELA1
Tchem
Family:  Enzyme
Novelty:  0.00290708
p_int:  0.990796747
p_ni:  0.007986881
p_wrong:  0.001216372
Score:  0.235
Data Source:  BioPlex,STRINGDB
THSD4
Tbio
Novelty:  0.12898073
p_int:  0.947541428
p_ni:  0.001430585
p_wrong:  0.051027988
Score:  0.27
Data Source:  BioPlex,STRINGDB
RCCD1
Tbio
Novelty:  0.07481641
p_int:  0.755965161
p_ni:  0.000903868
p_wrong:  0.243130971
Score:  0.28
Data Source:  BioPlex,STRINGDB
SUFU
Tbio
Novelty:  0.00475249
Score:  0.997
Data Source:  Reactome,STRINGDB
PTCH1
Tbio
Novelty:  0.00077635
Score:  0.99
Data Source:  STRINGDB
SMO
Tclin
Family:  GPCR
Novelty:  0.03235855
Score:  0.984
Data Source:  STRINGDB
SPOP
Tbio
Novelty:  0.00663363
Score:  0.977
Data Source:  Reactome,STRINGDB
BTRC
Tbio
Novelty:  0.00293475
Score:  0.972
Data Source:  STRINGDB
PTCH2
Tbio
Novelty:  0.00927849
Score:  0.965
Data Source:  STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
Score:  0.964
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1677.86

PubMed score by year
PubTator Score  259.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: