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Tchem
GLI2
Zinc finger protein GLI2

Protein Summary
Description
Functions as transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as transcriptional activator (PubMed:9557682, PubMed:19878745, PubMed:24311597). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). Isoform 1, isoform 2, isoform 3 and isoform 4: Act as transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Bind to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). Are involved in the smoothened (SHH) signaling pathway (PubMed:18455992). Isoform 5: Acts as a transcriptional repressor. This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361492
  • ENSP00000354586
  • ENSG00000074047
  • ENST00000452319
  • ENSP00000390436

Symbol
  • THP
  • CJS
  • HPE9
  • PHS2
  • THP1
  • THP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
0.94
PubMedID
0.74
disease
0.73
cell type or tissue
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 622.09   (req: < 5)
Gene RIFs: 119   (req: <= 3)
Antibodies: 285   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 622.09   (req: >= 5)
Gene RIFs: 119   (req: > 3)
Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 59
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (255)
SUFU
Tbio
Novelty:  0.00475249
Score:  0.999
Data Source:  Reactome,STRINGDB
STK36
Tbio
Family:  Kinase
Novelty:  0.0963277
Score:  0.996
Data Source:  STRINGDB
SHH
Tchem
Novelty:  0.00028347
Score:  0.996
Data Source:  STRINGDB
PTCH1
Tbio
Novelty:  0.00077635
Score:  0.992
Data Source:  STRINGDB
SMO
Tclin
Family:  GPCR
Novelty:  0.03235855
Score:  0.986
Data Source:  STRINGDB
SPOP
Tbio
Novelty:  0.00663363
Score:  0.978
Data Source:  Reactome,STRINGDB
CUL3
Tbio
Novelty:  0.0028737
Score:  0.973
Data Source:  Reactome,STRINGDB
ULK3
Tchem
Family:  Kinase
Novelty:  0.0783598
Score:  0.972
Data Source:  Reactome,STRINGDB
BTRC
Tbio
Novelty:  0.00293475
Score:  0.968
Data Source:  STRINGDB
PTCH2
Tbio
Novelty:  0.00927849
Score:  0.967
Data Source:  STRINGDB
Pathways (42)
Degradation of GLI2 by the proteasome (R-HSA-5610783)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of GLI2 by the proteasome
Reactome
GLI proteins bind promoters of Hh responsive genes to promote transcription
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Hedgehog 'off' state
Name
Explore in Pharos
Explore in Source
Degradation of GLI2 by the proteasome
GLI proteins bind promoters of Hh responsive genes to promote transcription
Gene expression (Transcription)
Generic Transcription Pathway
Hedgehog 'off' state
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (70)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
2
2
83.9
sex hormone-binding globulin measurement
6
3
7
71
balding measurement
1
2
2
59.3
urate measurement
5
1
5
55.5
triglyceride measurement
4
3
4
53
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
83.9
sex hormone-binding globulin measurement
7
71
balding measurement
2
59.3
urate measurement
5
55.5
triglyceride measurement
4
53
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GLI family zinc finger 2
VGNC:442
459582
Macaque
GLI family zinc finger 2
705877
Mouse
MGI:95728
14633
Rat
RGD:1309270
304729
Dog
GLI family zinc finger 2
VGNC:41257
100682984
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GLI family zinc finger 2
Macaque
GLI family zinc finger 2
Mouse
Rat
Dog
GLI family zinc finger 2
Publication Statistics
PubMed Score 622.09
PubMed score by year
PubTator Score 3183.05
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title