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Tdark
TUBA3D
Tubulin alpha-3D chain

Protein Summary
Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. This gene encodes a member of the alpha tubulin family. Tubulin is a major component of microtubules, which are composed of alpha- and beta-tubulin heterodimers and microtubule-associated proteins in the cytoskeleton. Microtubules maintain cellular structure, function in intracellular transport, and play a role in spindle formation during mitosis. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321253
  • ENSP00000326042
  • ENSG00000075886

Symbol
  • KTCN9
  • TUBA2
  • H2-ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.77   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.77   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
STMN4
Tbio
Novelty:  0.00422625
Score:  0.789
Data Source:  STRINGDB
MAPRE3
Tbio
Novelty:  0.00454315
Score:  0.782
Data Source:  STRINGDB
TUBB
Tclin
Novelty:  0.0038007
Score:  0.782
Data Source:  STRINGDB
MAPT
Tclin
Novelty:  0.00013232
Score:  0.767
Data Source:  STRINGDB
TUBB2A
Tclin
Novelty:  0.00902924
Score:  0.762
Data Source:  STRINGDB
TUBB3
Tclin
Novelty:  0.00195963
Score:  0.762
Data Source:  STRINGDB
NUF2
Tbio
Novelty:  0.01069726
Score:  0.757
Data Source:  STRINGDB
TUBB2B
Tclin
Novelty:  0.02905844
Score:  0.757
Data Source:  STRINGDB
CENPJ
Tbio
Novelty:  0.01337231
Score:  0.754
Data Source:  STRINGDB
NDC80
Tbio
Novelty:  0.00331814
Score:  0.749
Data Source:  STRINGDB
Nearest Tclin Targets (18)
Explore Nearest Tclin Targets
1 – 5 of 9
TUBB4B
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  3
TUBB
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  3
TUBB2A
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  3
TUBB2B
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  3
TUBB6
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  3
Pathways (16)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Reactome
Formation of tubulin folding intermediates by CCT/TriC
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Chaperonin-mediated protein folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Formation of tubulin folding intermediates by CCT/TriC
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubulin, alpha 3e
736248
Macaque
tubulin alpha 3c
707215
Mouse
MGI:1095408
22147
Rat
RGD:1565155
500363
Dog
tubulin alpha-3 chain-like
477570
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubulin, alpha 3e
Macaque
tubulin alpha 3c
Mouse
Rat
Dog
tubulin alpha-3 chain-like
Publication Statistics
PubMed Score 44.77
PubMed score by year
PubTator Score 2.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title