Tdark TUBA3D Tubulin alpha-3D chain

Protein Summary

Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. This gene encodes a member of the alpha tubulin family. Tubulin is a major component of microtubules, which are composed of alpha- and beta-tubulin heterodimers and microtubule-associated proteins in the cytoskeleton. Microtubules maintain cellular structure, function in intracellular transport, and play a role in spindle formation during mitosis. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• P0DPH8
• A6NJQ0
• Q13748
• Q5W099
• Q6PEY3
• Q96F18

Gene Name

• TUBA3D

Ensembl ID

• ENST00000321253
• ENSP00000326042
• ENSG00000075886

Symbol

• KTCN9
• TUBA2
• H2-ALPHA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.77   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.77   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (3)

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (68)

Explore Interacting Targets

1 – 10 of 68

• See Interactions on String-DB

STMN4

Tbio

Novelty:  0.00422625

Score:  0.789

Data Source:  STRINGDB

MAPRE3

Tbio

Novelty:  0.00454315

Score:  0.782

Data Source:  STRINGDB

TUBB

Tclin

Novelty:  0.0038007

Score:  0.782

Data Source:  STRINGDB

MAPT

Tclin

Novelty:  0.00013232

Score:  0.767

Data Source:  STRINGDB

TUBB2A

Tclin

Novelty:  0.00902924

Score:  0.762

Data Source:  STRINGDB

TUBB3

Tclin

Novelty:  0.00195963

Score:  0.762

Data Source:  STRINGDB

NUF2

Tbio

Novelty:  0.01069726

Score:  0.757

Data Source:  STRINGDB

TUBB2B

Tclin

Novelty:  0.02905844

Score:  0.757

Data Source:  STRINGDB

CENPJ

Tbio

Novelty:  0.01337231

Score:  0.754

Data Source:  STRINGDB

NDC80

Tbio

Novelty:  0.00331814

Score:  0.749

Data Source:  STRINGDB

Nearest Tclin Targets (18)

Explore Nearest Tclin Targets

Upstream (9)

Downstream (9)

1 – 5 of 9

TUBB4B

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  3

1: Phagosome

2: Gap junction

3: Pathogenic Escherichia coli infection

TUBB

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  3

1: Phagosome

2: Gap junction

3: Pathogenic Escherichia coli infection

TUBB2A

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  3

1: Phagosome

2: Gap junction

3: Pathogenic Escherichia coli infection

TUBB2B

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  3

1: Phagosome

2: Gap junction

3: Pathogenic Escherichia coli infection

TUBB6

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  3

1: Phagosome

2: Gap junction

3: Pathogenic Escherichia coli infection

Pathways (16)

Reactome (9)

KEGG (5)

WikiPathways (2)

Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

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1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Carboxyterminal post-translational modifications of tubulin	38 targets	R-HSA-8955332
Reactome	Chaperonin-mediated protein folding	96 targets	R-HSA-390466
Reactome	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	33 targets	R-HSA-389958
Reactome	Formation of tubulin folding intermediates by CCT/TriC	26 targets	R-HSA-389960
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Carboxyterminal post-translational modifications of tubulin	38 targets	R-HSA-8955332
Chaperonin-mediated protein folding	96 targets	R-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	33 targets	R-HSA-389958
Formation of tubulin folding intermediates by CCT/TriC	26 targets	R-HSA-389960
Metabolism of proteins	2050 targets	R-HSA-392499

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Functions (3)

Components (2)

Processes (1)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
GTP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
GTPase activity	Inferred from Electronic Annotation (IEA)	InterPro
structural constituent of cytoskeleton	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
GTP-binding
Isopeptide bond
Methylation
Microtubule
Nitration

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	tubulin, alpha 3e		736248
Macaque	tubulin alpha 3c		707215
Mouse	tubulin, alpha 3B	MGI:1095408	22147
Rat	tubulin, alpha 3B	RGD:1565155	500363
Dog	tubulin alpha-3 chain-like		477570

Species	Name	OMA	EggNOG	Inparanoid
Chimp	tubulin, alpha 3e
Macaque	tubulin alpha 3c
Mouse	tubulin, alpha 3B
Rat	tubulin, alpha 3B
Dog	tubulin alpha-3 chain-like

Publication Statistics

PubMed Score 44.77

PubMed score by year

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PubTator Score 2.71

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Related Publications

Text Mined References (10)

GeneRif Annotations (1)

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10

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PMID	Year	Title