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Tchem
TUBA3C
Tubulin alpha-3C chain

Protein Summary
Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene is an alpha tubulin gene that encodes a protein 99% identical to the mouse testis-specific Tuba3 and Tuba7 gene products. This gene is located in the 13q11 region, which is associated wit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000400113
  • ENSP00000382982
  • ENSG00000198033
  • ENST00000618094
  • ENSP00000482878

Symbol
  • TUBA2
  • TUBA2
  • bA408E5.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.88   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.88   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
podophyllotoxin
Rendered image for podophyllotoxin
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
21
6.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
21
6.3
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1095406
22144
Dog
tubulin alpha-3 chain
608051
Cow
tubulin, alpha 3e
534900
Pig
tubulin alpha-3 chain
100510930
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
tubulin alpha-3 chain
Cow
tubulin, alpha 3e
Pig
tubulin alpha-3 chain
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P0DPH7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Reactome
Formation of tubulin folding intermediates by CCT/TriC
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Chaperonin-mediated protein folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Formation of tubulin folding intermediates by CCT/TriC
Metabolism of proteins
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (126)
1 – 10 of 126
LGALS7
Tbio
Novelty:  0.00753996
p_int:  0.999999887
p_ni:  1.13e-7
Data Source:  BioPlex
TCP11L2
Tdark
Novelty:  1.78903335
p_int:  0.999999372
p_ni:  6.28e-7
Score:  0.641
Data Source:  BioPlex,STRINGDB
CHRM3
Tclin
Family:  GPCR
Novelty:  0.00849776
p_int:  0.99999923
p_ni:  7.7e-7
Data Source:  BioPlex
HDAC6
Tclin
Family:  Epigenetic
Novelty:  0.00122232
p_int:  0.99999557
p_ni:  0.00000443
Score:  0.174
Data Source:  BioPlex,STRINGDB
ATP6V0D1
Tbio
Family:  Enzyme
Novelty:  0.05146108
p_int:  0.999995432
p_ni:  0.000004568
Score:  0.18
Data Source:  BioPlex,STRINGDB
PML
Tbio
Novelty:  0.00285474
p_int:  0.999994601
p_ni:  0.000005399
Data Source:  BioPlex
P2RY8
Tbio
Family:  GPCR
Novelty:  0.05574297
p_int:  0.999991067
p_ni:  0.000008933
Data Source:  BioPlex
ARL4D
Tbio
Family:  Enzyme
Novelty:  0.13254344
p_int:  0.999983738
p_ni:  0.000016262
Score:  0.288
Data Source:  BioPlex,STRINGDB
KLRD1
Tbio
Novelty:  0.00218019
p_int:  0.999968477
p_ni:  0.000031518
p_wrong:  5e-9
Data Source:  BioPlex
FEZ1
Tbio
Novelty:  0.02695814
p_int:  0.999952625
p_ni:  0.000047375
Data Source:  BioPlex
Publication Statistics
PubMed Score  45.88

PubMed score by year
PubTator Score  6.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer