Protein Summary
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene is an alpha tubulin gene that encodes a protein 99% identical to the mouse testis-specific Tuba3 and Tuba7 gene products. This gene is located in the 13q11 region, which is associated wit ...more
- ENST00000400113
- ENSP00000382982
- ENSG00000198033
- ENST00000618094
- ENSP00000482878
- TUBA2
- TUBA2
- bA408E5.3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 45.88 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 45.88 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 21 | 6.3 | |||||
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GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 21 | 6.3 | |||||
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:1095406 | 22144 | ||||||
Dog | tubulin alpha-3 chain | 608051 | ||||||
Cow | tubulin, alpha 3e | 534900 | ||||||
Pig | tubulin alpha-3 chain | 100510930 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Dog | tubulin alpha-3 chain | |||||
Cow | tubulin, alpha 3e | |||||
Pig | tubulin alpha-3 chain | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (16)
Reactome (9)
KEGG (5)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 9
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Carboxyterminal post-translational modifications of tubulin | ||||
Reactome | Chaperonin-mediated protein folding | ||||
Reactome | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | ||||
Reactome | Formation of tubulin folding intermediates by CCT/TriC | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Carboxyterminal post-translational modifications of tubulin | ||||
Chaperonin-mediated protein folding | ||||
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | ||||
Formation of tubulin folding intermediates by CCT/TriC | ||||
Metabolism of proteins | ||||
Gene Ontology Terms (6)
Functions (3)
Components (2)
Processes (1)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (126)
1 – 10 of 126
LGALS7
Novelty: 0.00753996
p_int: 0.999999887
p_ni: 1.13e-7
Data Source: BioPlex
TCP11L2
Novelty: 1.78903335
p_int: 0.999999372
p_ni: 6.28e-7
Score: 0.641
Data Source: BioPlex,STRINGDB
CHRM3
Family: GPCR
Novelty: 0.00849776
p_int: 0.99999923
p_ni: 7.7e-7
Data Source: BioPlex
HDAC6
Family: Epigenetic
Novelty: 0.00122232
p_int: 0.99999557
p_ni: 0.00000443
Score: 0.174
Data Source: BioPlex,STRINGDB
ATP6V0D1
Family: Enzyme
Novelty: 0.05146108
p_int: 0.999995432
p_ni: 0.000004568
Score: 0.18
Data Source: BioPlex,STRINGDB
PML
Novelty: 0.00285474
p_int: 0.999994601
p_ni: 0.000005399
Data Source: BioPlex
P2RY8
Family: GPCR
Novelty: 0.05574297
p_int: 0.999991067
p_ni: 0.000008933
Data Source: BioPlex
ARL4D
Family: Enzyme
Novelty: 0.13254344
p_int: 0.999983738
p_ni: 0.000016262
Score: 0.288
Data Source: BioPlex,STRINGDB
KLRD1
Novelty: 0.00218019
p_int: 0.999968477
p_ni: 0.000031518
p_wrong: 5e-9
Data Source: BioPlex
FEZ1
Novelty: 0.02695814
p_int: 0.999952625
p_ni: 0.000047375
Data Source: BioPlex
Publication Statistics
PubMed Score 45.88
PubMed score by year
PubTator Score 6.17
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
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