You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ECE2
Endothelin-converting enzyme 2

Protein Summary
Description
Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May play a role in amyloid-beta processing (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357474
  • ENSP00000350066
  • ENSG00000145194
  • ENST00000359140
  • ENSP00000352052
  • ENST00000404464
  • ENSP00000385846

Symbol
  • KIAA0604
  • EEF1AKMT4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.73   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.73   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0