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Tbio
POLR1D
DNA-directed RNA polymerases I and III subunit RPAC2

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. The protein encoded by this gene is a component of the RNA polymerase I and RNA polymerase III complexes, which function in the synthesis of ribosomal RNA precursors and small RNAs, respectively. Mutations in this gene are a cause of Treacher Collins syndrome (TCS), a craniofacial development disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302979
  • ENSP00000302478
  • ENSG00000186184
  • ENST00000647448
  • ENSP00000495898

Symbol
  • AC19
  • RPA9
  • TCS2
  • RPA16
  • RPAC2
  • RPC16
  • POLR1C
  • RPO1-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.14   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.14   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
2
48.6
mathematical ability
1
1
2
48.6
1
1
2
37.9
1
1
2
37.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
48.6
mathematical ability
2
48.6
2
37.9
2
37.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase I and III subunit D
VGNC:13131
452506
Macaque
RNA polymerase I subunit D
718341
Mouse
MGI:108403
20018
Dog
DNA-directed RNA polymerases I and III subunit RPAC2
111092404
Horse
RNA polymerase I and III subunit D
VGNC:21671
100629435
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase I and III subunit D
Macaque
RNA polymerase I subunit D
Mouse
Dog
DNA-directed RNA polymerases I and III subunit RPAC2
Horse
RNA polymerase I and III subunit D
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P0DPB6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (28)
B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
B-WICH complex positively regulates rRNA expression
Cytosolic sensors of pathogen-associated DNA
Epigenetic regulation of gene expression
Gene expression (Transcription)
Immune System
Protein-Protein Interactions (316)
1 – 10 of 316
TWISTNB
Tdark
Family: Enzyme
Novelty: 0.59160737
Score: 0.999
Data Source: STRINGDB
POLR1C
Tbio
Family: Enzyme
Novelty: 0.04485332
Score: 0.999
Data Source: STRINGDB
POLR1A
Tchem
Family: Enzyme
Novelty: 0.0485107
Score: 0.999
Data Source: STRINGDB
POLR3C
Tbio
Family: Enzyme
Novelty: 0.05778457
Score: 0.999
Data Source: STRINGDB
POLR1B
Tbio
Family: Enzyme
Novelty: 0.06955307
Score: 0.999
Data Source: STRINGDB
POLR3D
Tbio
Family: Enzyme
Novelty: 0.02616321
Score: 0.999
Data Source: STRINGDB
POLR3A
Tbio
Family: Enzyme
Novelty: 0.01508849
Score: 0.999
Data Source: STRINGDB
POLR2H
Tbio
Family: Enzyme
Novelty: 0.04008409
Score: 0.999
Data Source: STRINGDB
POLR2E
Tbio
Family: Enzyme
Novelty: 0.01817288
Score: 0.999
Data Source: STRINGDB
POLR2L
Tbio
Family: Enzyme
Novelty: 0.03847579
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  86.14

PubMed score by year
PubTator Score  25.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer