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Tbio
P0DPB5
Protein POLR1D, isoform 2

Protein Summary
Description
The protein encoded by this gene is a component of the RNA polymerase I and RNA polymerase III complexes, which function in the synthesis of ribosomal RNA precursors and small RNAs, respectively. Mutations in this gene are a cause of Treacher Collins syndrome (TCS), a craniofacial development disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399697
  • ENSP00000382604
  • ENSG00000186184
  • ENST00000645412
  • ENSP00000496567

Symbol
  • AC19
  • RPA9
  • TCS2
  • RPA16
  • RPAC2
  • RPC16
  • POLR1C
  • RPO1-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.97
transcription factor binding site profile
0.86
histone modification site profile
0.79
small molecule perturbation
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.08   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.08   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (317)
POLR1C
Tbio
Family:  Enzyme
Novelty:  0.04485332
p_int:  0.996615653
p_ni:  0.003384302
p_wrong:  4.5e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
POLR3K
Tbio
Family:  Enzyme
Novelty:  0.07105011
p_int:  0.994882226
p_ni:  0.005117774
Score:  0.992
Data Source:  BioPlex,STRINGDB
RRN3
Tbio
Family:  Enzyme
Novelty:  0.01643149
p_int:  0.980808847
p_ni:  0.019191152
p_wrong:  2e-9
Score:  0.991
Data Source:  BioPlex,STRINGDB
POLR3D
Tbio
Family:  Enzyme
Novelty:  0.02616321
p_int:  0.953155345
p_ni:  0.046844655
Score:  0.999
Data Source:  BioPlex,STRINGDB
POLR3GL
Tdark
Family:  Enzyme
Novelty:  0.35648533
p_int:  0.9277436
p_ni:  0.072256387
p_wrong:  1.3e-8
Score:  0.982
Data Source:  BioPlex,STRINGDB
GPN3
Tbio
Family:  Enzyme
Novelty:  0.13817794
p_int:  0.906094266
p_ni:  0.093905527
p_wrong:  2.07e-7
Score:  0.931
Data Source:  BioPlex,STRINGDB
GPN1
Tbio
Family:  Enzyme
Novelty:  0.06883613
p_int:  0.786160496
p_ni:  0.213839504
Score:  0.23
Data Source:  BioPlex,STRINGDB
TWISTNB
Tdark
Family:  Enzyme
Novelty:  0.59160737
Score:  0.999
Data Source:  STRINGDB
POLR1A
Tchem
Family:  Enzyme
Novelty:  0.0485107
Score:  0.999
Data Source:  STRINGDB
POLR3C
Tbio
Family:  Enzyme
Novelty:  0.05778457
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (27)
B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
B-WICH complex positively regulates rRNA expression
Cytosolic sensors of pathogen-associated DNA
Epigenetic regulation of gene expression
Gene expression (Transcription)
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
1
6
80
age at first sexual intercourse measurement
1
2
4
46.8
1
1
2
17.8
mathematical ability
1
1
2
17.8
Hepatitis
1
1
0
1.1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
6
80
age at first sexual intercourse measurement
4
46.8
2
17.8
mathematical ability
2
17.8
Hepatitis
0
1.1
5.8
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase I and III subunit D
VGNC:13131
452506
Macaque
RNA polymerase I subunit D
718341
Mouse
MGI:108403
20018
Dog
DNA-directed RNA polymerases I and III subunit RPAC2
111092404
Horse
RNA polymerase I and III subunit D
VGNC:21671
100629435
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase I and III subunit D
Macaque
RNA polymerase I subunit D
Mouse
Dog
DNA-directed RNA polymerases I and III subunit RPAC2
Horse
RNA polymerase I and III subunit D
Publication Statistics
PubMed Score 88.08
PubMed score by year
PubTator Score 25.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title