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Tbio
DEFB130A
Beta-defensin 130A

Protein Summary
Description
Antimicrobial host-defense peptide. Has an antiplasmodial activity. Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 8p23. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000400079
  • ENSP00000382951
  • ENSG00000232948
  • ENST00000646760
  • ENSP00000495606
  • ENSG00000285249

Symbol
  • DEFB130
  • DEFB30
  • DEFB30
  • DEFB-30
  • DEFB130
  • DEFB130L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.75   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.75   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (22)
DEFB118
Tbio
Novelty:  0.14992977
Score:  0.706
Data Source:  STRINGDB
DEFB135
Tdark
Novelty:  2.04107063
Score:  0.634
Data Source:  STRINGDB
DEFB121
Tdark
Novelty:  2.72797456
Score:  0.625
Data Source:  STRINGDB
DEFB115
Tdark
Novelty:  0.51464209
Score:  0.603
Data Source:  STRINGDB
DEFB125
Tdark
Novelty:  0.69005738
Score:  0.563
Data Source:  STRINGDB
ODF3L1
Tdark
Novelty:  9.03484782
Score:  0.552
Data Source:  STRINGDB
DEFB116
Tdark
Novelty:  2.72622256
Score:  0.545
Data Source:  STRINGDB
DEFB127
Tbio
Novelty:  0.18126756
Score:  0.542
Data Source:  STRINGDB
DEFB128
Tbio
Novelty:  0.30093411
Score:  0.531
Data Source:  STRINGDB
KRTAP6-1
Tdark
Novelty:  0.3016588
Score:  0.508
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
3
3
92.2
neuroticism measurement
2
4
5
89.8
waist-hip ratio
1
4
4
79
BMI-adjusted waist-hip ratio
1
4
4
75.6
BMI-adjusted waist circumference
2
8
8
73
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
92.2
neuroticism measurement
5
89.8
waist-hip ratio
4
79
BMI-adjusted waist-hip ratio
4
75.6
BMI-adjusted waist circumference
8
73
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
defensin, beta 130
748166
Species
Name
OMA
EggNOG
Inparanoid
Chimp
defensin, beta 130
Publication Statistics
PubMed Score 1.75
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title