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Tbio
LYNX1
Ly-6/neurotoxin-like protein 1

Protein Summary
Description
Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs) (PubMed:21252236). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane. Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs. Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum. Shifts stoichiometry from high sensitivity alpha-4(2):beta-2(3) to low sensitivity alpha-4(3):beta-2(2) nAChR (By similarity). In vitro modulates alpha-3 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000614491
  • ENSP00000477648
  • ENSG00000180155
  • ENST00000620006
  • ENSP00000478402
  • ENST00000621401
  • ENSP00000478390
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.62
cell line
0.59
transcription factor
0.48
tissue
0.47
transcription factor perturbation
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.67   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.67   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (17)
1 – 10 of 17
CHRNA7
Tchem
Family: IC
Novelty: 0.00590784
Score: 0.812
Data Source: STRINGDB
SLURP1
Tbio
Novelty: 0.00710864
Score: 0.807
Data Source: STRINGDB
CHRNA4
Tclin
Family: IC
Novelty: 0.00494934
Score: 0.708
Data Source: STRINGDB
LY6H
Tbio
Novelty: 0.10210816
Score: 0.686
Data Source: STRINGDB
LYPD2
Tdark
Novelty: 0.55307434
Score: 0.669
Data Source: STRINGDB
GML
Tdark
Novelty: 0.04982168
Score: 0.55
Data Source: STRINGDB
LY6K
Tbio
Novelty: 0.01861325
Score: 0.543
Data Source: STRINGDB
LYPD6
Tbio
Novelty: 0.13867181
Score: 0.537
Data Source: STRINGDB
CHRNA1
Tclin
Family: IC
Novelty: 0.01393364
Score: 0.529
Data Source: STRINGDB
LYPD1
Tbio
Novelty: 0.10740408
Score: 0.507
Data Source: STRINGDB
Publication Statistics
PubMed Score  31.67

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer