Protein Summary
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. This gene encodes a member of a family of proteins that binds calcium and functions as a enzymatic co-factor. Activity of this protein is important in the regulation of the cell cycle and cytokinesis. Multiple alternatively spliced transcript variants have been observed at this gene. [provided by RefSeq, Aug 2016]
- ENST00000291295
- ENSP00000291295
- ENSG00000160014
- ENST00000596362
- ENSP00000472141
- CALML2
- CAM3
- CAMC
- CAMIII
- CaM
- CALM
- CAM1
- CAM2
- CAMB
- PHKD
- PHKD3
- CaMIII
- HEL-S-72
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 207.33 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 207.33 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 46
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (0)
Protein-Protein Interactions (289)
CD33
Novelty: 0.00074958
p_int: 0.956380518
p_ni: 0.043619482
Score: 0.379
Data Source: BioPlex,STRINGDB
MYLK3
Family: Kinase
Novelty: 0.00661904
p_int: 0.947514665
p_ni: 0.052485335
Score: 0.762
Data Source: BioPlex,STRINGDB
CAMK1D
Family: Kinase
Novelty: 0.0274233
p_int: 0.907824522
p_ni: 0.092175478
Score: 0.914
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (45)
KEGG (40)
WikiPathways (5)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Inflammatory mediator regulation of TRP channels | ||||
KEGG | Aldosterone synthesis and secretion | ||||
KEGG | Oxytocin signaling pathway | ||||
KEGG | Kaposi sarcoma-associated herpesvirus infection | ||||
KEGG | Gastric acid secretion | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Inflammatory mediator regulation of TRP channels | ||||
Aldosterone synthesis and secretion | ||||
Oxytocin signaling pathway | ||||
Kaposi sarcoma-associated herpesvirus infection | ||||
Gastric acid secretion | ||||
Viral Interactions (0)
Gene Ontology Terms (62)
Functions (16)
Components (16)
Processes (30)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 1 | 1 | 1 | 80.9 | |||||
heel bone mineral density | 2 | 1 | 2 | 62.1 | |||||
reticulocyte count | 1 | 1 | 1 | 55.2 | |||||
2 | 1 | 0 | 1.3 | 54.4 | |||||
1 | 1 | 0 | 1.2 | 48.5 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte measurement | 1 | 80.9 | |||||
heel bone mineral density | 2 | 62.1 | |||||
reticulocyte count | 1 | 55.2 | |||||
0 | 1.3 | 54.4 | |||||
0 | 1.2 | 48.5 | |||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 207.33
PubMed score by year
PubTator Score 474.98
PubTator score by year
Related Publications
Text Mined References (151)
GeneRif Annotations (14)
Items per page:
0 of 0
PMID | Year | Title |
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