Tclin CALM3 Calmodulin-3

Protein Classes

PANTHER Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Calmodulin-3

DTO Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Calmodulin-3

Protein Summary

Description

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. This gene encodes a member of a family of proteins that binds calcium and functions as a enzymatic co-factor. Activity of this protein is important in the regulation of the cell cycle and cytokinesis. Multiple alternatively spliced transcript variants have been observed at this gene. [provided by RefSeq, Aug 2016]

Uniprot Accession IDs

• P0DP25
• P02593
• P62158
• P70667
• P99014
• Q13942
• Q53S29
• Q61379
• Q61380
• Q96HK3

Gene Name

• CALM3

Ensembl ID

• ENST00000291295
• ENSP00000291295
• ENSG00000160014
• ENST00000596362
• ENSP00000472141

Symbol

• CALML2
• CAM3
• CAMC
• CAMIII
• CaM
• CALM
• CAM1
• CAM2
• CAMB
• PHKD
• PHKD3
• CaMIII
• HEL-S-72

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 204.16   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 204.16   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

aprindine

CALM3Tclin

INHIBITOR ID50 : 4.7447

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	1	1	1		51.8
ulcerative colitis	EFO_0000729	1	1	0	1.1	3.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	1		51.8
ulcerative colitis	EFO_0000729	0	1.1	3.5

Reset Zoom  Beta Count   Odds Ratio

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-P0DP25-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (45)

KEGG (40)

WikiPathways (5)

Find Similar Targets

Items per page:

5

1 – 5 of 40

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Inflammatory mediator regulation of TRP channels	102 targets	path:hsa04750
KEGG	Aldosterone synthesis and secretion	101 targets	path:hsa04925
KEGG	Oxytocin signaling pathway	155 targets	path:hsa04921
KEGG	Kaposi sarcoma-associated herpesvirus infection	252 targets	path:hsa05167
KEGG	Gastric acid secretion	78 targets	path:hsa04971

Name	Explore in Pharos	Explore in Source
Inflammatory mediator regulation of TRP channels	102 targets	path:hsa04750
Aldosterone synthesis and secretion	101 targets	path:hsa04925
Oxytocin signaling pathway	155 targets	path:hsa04921
Kaposi sarcoma-associated herpesvirus infection	252 targets	path:hsa05167
Gastric acid secretion	78 targets	path:hsa04971

Gene Ontology Terms (62)

Functions (16)

Components (16)

Processes (30)

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Items per page:

10

1 – 10 of 16

GO Term	Evidence	Assigned by
adenylate cyclase activator activity	Inferred from Direct Assay (IDA)	UniProtKB
calcium ion binding	Inferred from Direct Assay (IDA)	UniProtKB
protein phosphatase activator activity	Inferred from Direct Assay (IDA)	BHF-UCL
adenylate cyclase binding	Inferred from Physical Interaction (IPI)	CAFA
disordered domain specific binding	Inferred from Physical Interaction (IPI)	CAFA
ion channel binding	Inferred from Physical Interaction (IPI)	BHF-UCL
N-terminal myristoylation domain binding	Inferred from Physical Interaction (IPI)	UniProtKB
protein domain specific binding	Inferred from Physical Interaction (IPI)	UniProtKB
protein kinase binding	Inferred from Physical Interaction (IPI)	BHF-UCL
titin binding	Inferred from Physical Interaction (IPI)	BHF-UCL

Protein-Protein Interactions (289)

Explore Interacting Targets

1 – 10 of 289

• See Interactions on String-DB

CD33

Tclin

Novelty: 0.00074958

p_int: 0.956380518

p_ni: 0.043619482

Score: 0.379

Data Source: BioPlex,STRINGDB

MYLK3

Tchem

Family: Kinase

Novelty: 0.00661904

p_int: 0.947514665

p_ni: 0.052485335

Score: 0.762

Data Source: BioPlex,STRINGDB

CAMK1D

Tchem

Family: Kinase

Novelty: 0.0274233

p_int: 0.907824522

p_ni: 0.092175478

Score: 0.914

Data Source: BioPlex,STRINGDB

MYLK

Tchem

Family: Kinase

Novelty: 0.00102277

Score: 0.991

Data Source: STRINGDB

CACNA1C

Tclin

Family: IC

Novelty: 0.00099998

Score: 0.986

Data Source: STRINGDB

KCNN2

Tchem

Family: IC

Novelty: 0.01865346

Score: 0.985

Data Source: STRINGDB

CAMK2D

Tchem

Family: Kinase

Novelty: 0.02326864

Score: 0.983

Data Source: STRINGDB

PPP3CA

Tchem

Family: Enzyme

Novelty: 0.00234189

Score: 0.979

Data Source: STRINGDB

DAPK1

Tchem

Family: Kinase

Novelty: 0.0031894

Score: 0.978

Data Source: STRINGDB

KCNQ3

Tclin

Family: IC

Novelty: 0.00547886

Score: 0.973

Data Source: STRINGDB

Publication Statistics

PubMed Score  204.16

PubMed score by year

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PubTator Score  474.98

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Acetylation
Calcium
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
Isopeptide bond
Long QT syndrome
Metal-binding

GWAS Trait Find Similar Targets

reticulocyte measurement
ulcerative colitis