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Tclin
CALM2
Calmodulin-2

Protein Summary
Description
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272298
  • ENSP00000272298
  • ENSG00000143933

Symbol
  • CAM2
  • CAMB
  • caM
  • CALM
  • CAM1
  • CAM3
  • CAMC
  • PHKD
  • CAMII
  • LQT15
  • PHKD2
  • CALML2
  • CAMIII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.9   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.9   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
aprindine
chemical structure image
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:103249
12315
Dog
calmodulin 1
480416
Horse
calmodulin 2
100629145
Cow
calmodulin 2
100297344
Pig
calmodulin 2
100522926
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
calmodulin 1
Horse
calmodulin 2
Cow
calmodulin 2
Pig
calmodulin 2
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P0DP24-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (58)
Items per page:
1 – 5 of 40
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Inflammatory mediator regulation of TRP channels
KEGG
Aldosterone synthesis and secretion
KEGG
Oxytocin signaling pathway
KEGG
Kaposi sarcoma-associated herpesvirus infection
KEGG
Gastric acid secretion
Name
Explore in Pharos
Explore in Source
Inflammatory mediator regulation of TRP channels
Aldosterone synthesis and secretion
Oxytocin signaling pathway
Kaposi sarcoma-associated herpesvirus infection
Gastric acid secretion
Gene Ontology Terms (47)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (206)
1 – 10 of 206
CACNA1C
Tclin
Family: IC
Novelty: 0.00099998
Score: 0.979
Data Source: STRINGDB
CAMK2D
Tchem
Family: Kinase
Novelty: 0.02326864
Score: 0.978
Data Source: STRINGDB
MYLK
Tchem
Family: Kinase
Novelty: 0.00102277
Score: 0.978
Data Source: STRINGDB
PPP3CA
Tchem
Family: Enzyme
Novelty: 0.00234189
Score: 0.973
Data Source: STRINGDB
KCNQ3
Tclin
Family: IC
Novelty: 0.00547886
Score: 0.972
Data Source: STRINGDB
KCNN2
Tchem
Family: IC
Novelty: 0.01865346
Score: 0.97
Data Source: STRINGDB
SCN2A
Tclin
Family: IC
Novelty: 0.0007317
Score: 0.965
Data Source: STRINGDB
NOS2
Tchem
Family: Enzyme
Novelty: 0.00034846
Score: 0.965
Data Source: STRINGDB
DAPK1
Tchem
Family: Kinase
Novelty: 0.0031894
Score: 0.964
Data Source: STRINGDB
AKAP5
Tbio
Family: Enzyme
Novelty: 0.00351101
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  44.90

PubMed score by year
PubTator Score  28.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer