Tclin CALM1 Calmodulin-1

Protein Summary

Description

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• P0DP23
• P02593
• P62158
• P70667
• P99014
• Q13942
• Q53S29
• Q61379
• Q61380
• Q96HK3

Gene Name

• CALM1

Ensembl ID

• ENST00000356978
• ENSP00000349467
• ENSG00000198668

Symbol

• CALM
• CAM
• CAM1
• caM
• CAM2
• CAM3
• CAMB
• CAMC
• CAMI
• PHKD
• CPVT4
• DD132
• LQT14
• CALML2
• CAMIII

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	1
hub protein	0.97
pathway	0.97
transcription factor perturbation	0.91
transcription factor binding site profile	0.83

Protein Classes

PANTHER Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Calmodulin-1

DTO Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Calmodulin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 432.97   (req: < 5)

Gene RIFs: 210   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 432.97   (req: >= 5)

Gene RIFs: 210   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2