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Tdark
U2AF1L5
Splicing factor U2AF 35 kDa subunit-like protein

Protein Summary
Description
Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610664
  • ENSP00000485022
  • ENSG00000275895
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
1
protein complex
0.83
transcription factor binding site profile
0.69
histone modification site profile
0.66


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.06   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.06   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P0DN76-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (204)
1 – 10 of 204
U2AF2
Tbio
Novelty:  0.00590935
Score:  0.999
Data Source:  STRINGDB
HNRNPM
Tbio
Novelty:  0.0125566
Score:  0.96
Data Source:  STRINGDB
HNRNPA1
Tchem
Novelty:  0.0020871
Score:  0.956
Data Source:  STRINGDB
SRSF3
Tbio
Novelty:  0.01015895
Score:  0.953
Data Source:  STRINGDB
HNRNPA2B1
Tbio
Novelty:  0.00404935
Score:  0.949
Data Source:  STRINGDB
PTBP1
Tbio
Novelty:  0.00184728
Score:  0.949
Data Source:  STRINGDB
HNRNPH1
Tbio
Novelty:  0.01273351
Score:  0.949
Data Source:  STRINGDB
U2AF1
Tbio
Novelty:  0.01181981
Score:  0.941
Data Source:  STRINGDB
CTNNBL1
Tbio
Novelty:  0.0189038
Score:  0.94
Data Source:  STRINGDB
DDX39B
Tbio
Family:  Enzyme
Novelty:  0.012548
Score:  0.933
Data Source:  STRINGDB
Publication Statistics
PubMed Score  94.06

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer