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Tbio
HSPA1B
Heat shock 70 kDa protein 1B

Protein Summary
Description
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375650
  • ENSP00000364801
  • ENSG00000204388
  • ENST00000391548
  • ENSP00000375391
  • ENSG00000224501
  • ENST00000391555
  • ENSP00000375399
  • ENSG00000212866
  • ENST00000445736
  • ENSP00000403530
  • ENSG00000231555
  • ENST00000450744
  • ENSP00000393087
  • ENSG00000232804

Symbol
  • HSP72
  • HSP72
  • HSPA1
  • HSX70
  • HSP70-1
  • HSP70-2
  • HSP70.1
  • HSP70.2
  • HSP70-1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.95   (req: < 5)
Gene RIFs: 84   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.95   (req: >= 5)
Gene RIFs: 84   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (268)
Items per page:
1 – 5 of 268
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
5
15
19
97.9
BMI-adjusted waist-hip ratio
5
15
19
97.9
BMI-adjusted waist-hip ratio
5
15
19
97.9
BMI-adjusted waist-hip ratio
5
15
19
97.9
3
3
0
2.3
96
Items per page:
1 – 5 of 268
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
19
97.9
BMI-adjusted waist-hip ratio
19
97.9
BMI-adjusted waist-hip ratio
19
97.9
BMI-adjusted waist-hip ratio
19
97.9
0
2.3
96
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family A (Hsp70) member 1A
745166
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family A (Hsp70) member 1A
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P0DMV9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (527)
Attenuation phase (R-HSA-3371568)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Attenuation phase
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
HSF1 activation
Name
Explore in Pharos
Explore in Source
Attenuation phase
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
HSF1 activation
Gene Ontology Terms (65)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (155)
1 – 10 of 155
KLHL34
Tdark
Novelty:  2.18471039
p_int:  0.88162142
p_ni:  0.11837858
Score:  0.275
Data Source:  BioPlex,STRINGDB
SLC27A3
Tbio
Family:  Transporter
Novelty:  0.1037612
p_int:  0.774933201
p_ni:  0.225066799
Score:  0.239
Data Source:  BioPlex,STRINGDB
HSP90AA1
Tchem
Novelty:  0.00016774
Score:  0.985
Data Source:  Reactome,STRINGDB
BAG5
Tbio
Novelty:  0.0318404
Score:  0.985
Data Source:  STRINGDB
HSP90AB1
Tchem
Novelty:  0.00907961
Score:  0.984
Data Source:  Reactome,STRINGDB
DNAJB1
Tbio
Novelty:  0.00139956
Score:  0.982
Data Source:  Reactome,STRINGDB
HSPA1A
Tchem
Novelty:  0.00069195
Score:  0.981
Data Source:  STRINGDB
STIP1
Tbio
Novelty:  0.00590952
Score:  0.979
Data Source:  Reactome,STRINGDB
DNAJA4
Tbio
Novelty:  0.15880924
Score:  0.974
Data Source:  Reactome,STRINGDB
BAG3
Tbio
Novelty:  0.0042967
Score:  0.974
Data Source:  STRINGDB
Publication Statistics
PubMed Score  67.95

PubMed score by year
PubTator Score  71.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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