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Tchem
HSPA1A
Heat shock 70 kDa protein 1A

Protein Summary
Description
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375651
  • ENSP00000364802
  • ENSG00000204389
  • ENST00000400040
  • ENSP00000382915
  • ENSG00000215328
  • ENST00000430065
  • ENSP00000404524
  • ENSG00000235941
  • ENST00000433487
  • ENSP00000408907
  • ENSG00000234475
  • ENST00000441618
  • ENSP00000406359
  • ENSG00000237724

Symbol
  • HSP72
  • HSPA1
  • HSX70
  • HSP72
  • HSPA1
  • HSP70I
  • HSP70-1
  • HSP70-2
  • HSP70.1
  • HSP70.2
  • HSP70-1A
  • HEL-S-103
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1518.97   (req: < 5)
Gene RIFs: 243   (req: <= 3)
Antibodies: 2147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1518.97   (req: >= 5)
Gene RIFs: 243   (req: > 3)
Antibodies: 2147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
11.5
monocyte count
1
1
1
4.1
lymphocyte count
1
1
1
4.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
11.5
monocyte count
1
4.1
lymphocyte count
1
4.1
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:99517
15511
Horse
heat shock 70kDa protein 1A
100050827
Cow
heat shock 70kDa protein 1A
282254
Zebrafish
ZDB-GENE-050321-1
560210
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Horse
heat shock 70kDa protein 1A
Cow
heat shock 70kDa protein 1A
Zebrafish
Protein Data Bank (38)
1 – 5 of 38
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (40)
AUF1 (hnRNP D0) binds and destabilizes mRNA (R-HSA-450408)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AUF1 (hnRNP D0) binds and destabilizes mRNA
Reactome
Attenuation phase
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
AUF1 (hnRNP D0) binds and destabilizes mRNA
Attenuation phase
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Gene Ontology Terms (77)
Items per page:
10
1 – 10 of 20
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Protein-Protein Interactions (361)
1 – 10 of 361
ELP4
Tbio
Novelty: 0.03734233
p_int: 1
Data Source: BioPlex
SPATA5L1
Tdark
Family: Enzyme
Novelty: 0.5393372
p_int: 0.999999999
Score: 0.303
Data Source: BioPlex,STRINGDB
VWCE
Tbio
Novelty: 0.09328341
p_int: 0.999999964
p_ni: 3.6e-8
Score: 0.156
Data Source: BioPlex,STRINGDB
GMFB
Tbio
Novelty: 0.01531815
p_int: 0.99999973
p_ni: 2.7e-7
Data Source: BioPlex
DRC3
Tdark
Novelty: 0.99283468
p_int: 0.999999654
p_ni: 3.46e-7
Data Source: BioPlex
ASAP3
Tbio
Novelty: 0.06898579
p_int: 0.99999913
p_ni: 8.7e-7
Score: 0.278
Data Source: BioPlex,STRINGDB
PLCD4
Tbio
Family: Enzyme
Novelty: 0.07014141
p_int: 0.999999096
p_ni: 9.04e-7
Data Source: BioPlex
FSCN1
Tbio
Novelty: 0.00221877
p_int: 0.999999017
p_ni: 9.83e-7
Data Source: BioPlex
CD96
Tbio
Novelty: 0.02087722
p_int: 0.999993408
p_ni: 0.000006592
Score: 0.345
Data Source: BioPlex,STRINGDB
NUDT3
Tbio
Family: Enzyme
Novelty: 0.06052313
p_int: 0.999993174
p_ni: 0.000006826
Data Source: BioPlex
Publication Statistics
PubMed Score  1518.97

PubMed score by year
PubTator Score  658.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer