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Tchem
TMIGD3
Transmembrane domain-containing protein TMIGD3

Protein Summary
Description
Isoform 1: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity (PubMed:27886186). This gene encodes a transmembrane and immunoglobulin domain-containing protein. Alternative splicing results in multiple transcript variants, one of which shares its 5' terminal exon with that of the overlapping adenosine A3 receptor gene (GeneID:140), thus resulting in a fusion product. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369716
  • ENSP00000358730
  • ENSG00000121933
  • ENST00000369717
  • ENSP00000358731

Symbol
  • AD026
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1461.81   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1461.81   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 100
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
2
66.6
lymphocyte count
1
1
1
38.2
mathematical ability
1
1
1
30.2
1
1
0
1.1
30.2
intelligence
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
66.6
lymphocyte count
1
38.2
mathematical ability
1
30.2
0
1.1
30.2
intelligence
1
17.8
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenosine A3 receptor
457108
Horse
transmembrane and immunoglobulin domain containing 3
VGNC:50897
100063300
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenosine A3 receptor
Horse
transmembrane and immunoglobulin domain containing 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P0DMS9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (307)
1 – 10 of 307
P2RY12
Tclin
Family:  GPCR
Novelty:  0.00035406
Score:  0.968
Data Source:  STRINGDB
P2RY13
Tchem
Family:  GPCR
Novelty:  0.01511227
Score:  0.966
Data Source:  STRINGDB
P2RY4
Tchem
Family:  GPCR
Novelty:  0.00903213
Score:  0.956
Data Source:  STRINGDB
P2RY14
Tchem
Family:  GPCR
Novelty:  0.0135462
Score:  0.955
Data Source:  STRINGDB
ADRA2A
Tclin
Family:  GPCR
Novelty:  0.00273659
Score:  0.953
Data Source:  STRINGDB
OPRL1
Tchem
Family:  GPCR
Novelty:  0.00186729
Score:  0.953
Data Source:  STRINGDB
CNR1
Tclin
Family:  GPCR
Novelty:  0.00060063
Score:  0.952
Data Source:  STRINGDB
OPRM1
Tclin
Family:  GPCR
Novelty:  0.0003701
Score:  0.95
Data Source:  STRINGDB
OPRD1
Tclin
Family:  GPCR
Novelty:  0.00757692
Score:  0.95
Data Source:  STRINGDB
OPRK1
Tclin
Family:  GPCR
Novelty:  0.00171044
Score:  0.949
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1461.81

PubMed score by year
PubTator Score  0.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer