Protein Summary
Isoform 2: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase (PubMed:8234299). Isoform 1: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity (PubMed:27886186). This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobuli ...more
- ENST00000241356
- ENSP00000241356
- ENSG00000282608
- A3AR
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
ligand (chemical) | 1 | ||
biological process | 0.95 | ||
gene perturbation | 0.65 | ||
chemical | 0.64 | ||
disease | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1630.19 (req: < 5)
Gene RIFs: 57 (req: <= 3)
Antibodies: 116 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1630.19 (req: >= 5)
Gene RIFs: 57 (req: > 3)
Antibodies: 116 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2031
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 23
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (23)
Active Ligands (2031)
Protein-Protein Interactions (313)
TBC1D9B
Novelty: 0.66719861
p_int: 0.99930851
p_ni: 0.00069149
Score: 0.227
Data Source: BioPlex,STRINGDB
ATP12A
Family: Transporter
Novelty: 0.00008793
p_int: 0.969060768
p_ni: 0.030932701
p_wrong: 0.000006532
Score: 0.178
Data Source: BioPlex,STRINGDB
TMEM11
Novelty: 0.00067837
p_int: 0.967365865
p_ni: 0.015772435
p_wrong: 0.016861699
Score: 0.208
Data Source: BioPlex,STRINGDB
IPO9
Novelty: 0.03978028
p_int: 0.931299544
p_ni: 0.068700456
Score: 0.193
Data Source: BioPlex,STRINGDB
CAND2
Novelty: 0.08940552
p_int: 0.878132634
p_ni: 0.121867366
Score: 0.165
Data Source: BioPlex,STRINGDB
IPO11
Novelty: 0.09553616
p_int: 0.76819606
p_ni: 0.231803898
p_wrong: 4.1e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (22)
Reactome (8)
KEGG (3)
PathwayCommons (2)
WikiPathways (9)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adenosine P1 receptors | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adenosine P1 receptors | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (1)
Components (2)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
leukocyte count | 2 | 2 | 2 | 65.9 | |||||
neutrophil count | 1 | 1 | 1 | 45 | |||||
energy intake measurement | 1 | 1 | 0 | 145 | 38.7 | ||||
lymphocyte count | 1 | 1 | 1 | 28.6 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
leukocyte count | 2 | 65.9 | |||||
neutrophil count | 1 | 45 | |||||
energy intake measurement | 0 | 145 | 38.7 | ||||
lymphocyte count | 1 | 28.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (5)
1 – 5 of 5
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:104847 | 11542 | ||||||
Dog | adenosine A3 receptor | VGNC:37668 | 403805 | |||||
Cow | adenosine A3 receptor | 780806 | ||||||
Pig | transmembrane and immunoglobulin domain containing 3 isoform 3 [Source:RefSeq peptide;Acc:NP_001289700] | |||||||
Chicken | adenosine A3 receptor | CGNC:48977 | 373956 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Dog | adenosine A3 receptor | |||||
Cow | adenosine A3 receptor | |||||
Pig | transmembrane and immunoglobulin domain containing 3 isoform 3 [Source:RefSeq peptide;Acc:NP_001289700] | |||||
Chicken | adenosine A3 receptor | |||||
Publication Statistics
PubMed Score 1630.19
PubMed score by year
PubTator Score 255.01
PubTator score by year
Related Publications
Text Mined References (93)
GeneRif Annotations (57)
Items per page:
0 of 0
PMID | Year | Title |
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