Tchem ADORA3 Adenosine receptor A3

Protein Summary

Description

Isoform 2: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase (PubMed:8234299). Isoform 1: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity (PubMed:27886186). This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]

Uniprot Accession IDs

• P0DMS8
• A2A3P4
• P33765
• Q6UWU0
• Q9BYZ1

Gene Name

• ADORA3

Ensembl ID

• ENST00000241356
• ENSP00000241356
• ENSG00000282608

Symbol

• A3AR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	1
biological process	0.95
gene perturbation	0.65
chemical	0.64
disease	0.62

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Adenosine Receptor A3

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Adenosine Receptor / Adenosine Receptor A3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1630.19   (req: < 5)

Gene RIFs: 67   (req: <= 3)

Antibodies: 116   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1630.19   (req: >= 5)

Gene RIFs: 67   (req: > 3)

Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2031

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 23