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Tdark
SULT1A4
Sulfotransferase 1A4

Protein Summary
Description
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16, this gene and SULT1A3 arose from a segmental duplication. Read-through transcription exists between this gene and the upstream SLX1B (SLX1 structure-specific endonuclease subunit homolog B) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360423
  • ENSP00000353600
  • ENSG00000213648

Symbol
  • STM
  • HAST3
  • M-PST
  • ST1A3
  • ST1A4
  • TL-PST
  • ST1A3/ST1A4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.27   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.27   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (9)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytosolic sulfonation of small molecules
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytosolic sulfonation of small molecules
Metabolism
Phase II - Conjugation of compounds
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (11)
1 – 10 of 11
SULT1A3
Tbio
Family: Enzyme
Novelty: 0.00335383
Score: 0.819
Data Source: STRINGDB
SULT1A1
Tbio
Family: Enzyme
Novelty: 0.00238409
Score: 0.565
Data Source: STRINGDB
SULT1A2
Tbio
Family: Enzyme
Novelty: 0.01102416
Score: 0.553
Data Source: STRINGDB
PSMB4
Tbio
Family: Enzyme
Novelty: 0.0376233
Score: 0.502
Data Source: STRINGDB
BOLA2
Tbio
Novelty: 0.18144236
Score: 0.474
Data Source: STRINGDB
ZNF773
Tdark
Family: TF
Novelty: 0.99356549
Score: 0.445
Data Source: STRINGDB
SPNS1
Tbio
Novelty: 0.05524405
Score: 0.431
Data Source: STRINGDB
TCEANC2
Tdark
Novelty: 0.40325323
Score: 0.426
Data Source: STRINGDB
KCTD13
Tbio
Novelty: 0.07000508
Score: 0.424
Data Source: STRINGDB
BPNT1
Tbio
Family: Enzyme
Novelty: 0.1114547
Score: 0.422
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.27

PubMed score by year
PubTator Score  6.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer