Tbio SULT1A3 Sulfotransferase 1A3

Protein Summary

Description

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease subunit homolog A) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• P0DMM9
• B4DNV0
• O95603
• P50224
• Q1ET66
• Q6ZWJ5
• ST1A3

Gene Name

• SULT1A3

Ensembl ID

• ENST00000338971
• ENSP00000343645
• ENSG00000261052
• ENST00000395138
• ENSP00000378570
• ENST00000563322
• ENSP00000454518

Symbol

• STM
• STM
• HAST
• HAST3
• M-PST
• ST1A3
• ST1A4
• ST1A5
• TL-PST
• ST1A3/ST1A4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	0.77
tissue	0.6
tissue sample	0.6
cell line	0.5
pathway	0.47

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 537.05   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 181   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 537.05   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0