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Tbio
SULT1A3
Sulfotransferase 1A3

Protein Summary
Description
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease subunit homolog A) gene that encodes a protein containin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338971
  • ENSP00000343645
  • ENSG00000261052
  • ENST00000395138
  • ENSP00000378570
  • ENST00000563322
  • ENSP00000454518

Symbol
  • STM
  • STM
  • HAST
  • HAST3
  • M-PST
  • ST1A3
  • ST1A4
  • ST1A5
  • TL-PST
  • ST1A3/ST1A4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.77
tissue
0.6
tissue sample
0.6
cell line
0.5
pathway
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.17   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.17   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (32)
1 – 10 of 32
SULT1A2
Tbio
Family:  Enzyme
Novelty:  0.01102416
p_int:  0.999999993
p_ni:  6e-9
p_wrong:  1e-9
Score:  0.868
Data Source:  BioPlex,STRINGDB
SULT1A1
Tchem
Family:  Enzyme
Novelty:  0.00238409
p_int:  0.99999998
p_ni:  2e-8
Score:  0.934
Data Source:  BioPlex,STRINGDB
MPPED2
Tbio
Family:  Enzyme
Novelty:  0.091909
p_int:  0.987699154
p_ni:  0.012300846
Score:  0.393
Data Source:  BioPlex,STRINGDB
SULT4A1
Tbio
Family:  Enzyme
Novelty:  0.02455678
p_int:  0.962489206
p_ni:  0.037510794
Score:  0.845
Data Source:  BioPlex,STRINGDB
SULT1C2
Tbio
Family:  Enzyme
Novelty:  0.02956075
p_int:  0.905795058
p_ni:  0.094204942
Score:  0.879
Data Source:  BioPlex,STRINGDB
TTC1
Tbio
Novelty:  0.01389711
p_int:  0.777117227
p_ni:  0.222882772
p_wrong:  1e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
THBD
Tbio
Novelty:  0.00039359
Score:  0.84
Data Source:  STRINGDB
SULT1A4
Tdark
Family:  Enzyme
Novelty:  1.36001222
Score:  0.819
Data Source:  STRINGDB
GOT1
Tbio
Family:  Enzyme
Novelty:  0.00448817
Score:  0.74
Data Source:  STRINGDB
VWF
Tclin
Novelty:  0.00009007
Score:  0.635
Data Source:  STRINGDB
Pathways (11)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytosolic sulfonation of small molecules
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytosolic sulfonation of small molecules
IRE1alpha activates chaperones
Metabolism
Metabolism of proteins
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
34.9
diastolic blood pressure
1
1
1
14.1
1
1
0
1.1
9.3
1
1
0
1.2
0.2
tonsillectomy risk measurement
1
1
0
1.1
0.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
34.9
diastolic blood pressure
1
14.1
0
1.1
9.3
0
1.2
0.2
tonsillectomy risk measurement
0
1.1
0.2
Find similar targets by:
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
100428398
Mouse
MGI:102896
20887
Rat
RGD:3767
83783
Cow
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
282485
Opossum
sulfotransferase 1A1
100013048
Species
Name
OMA
EggNOG
Inparanoid
Macaque
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
Mouse
Rat
Cow
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
Opossum
sulfotransferase 1A1
Publication Statistics
PubMed Score 336.17
PubMed score by year
PubTator Score 791.88
PubTator score by year