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Tbio
CSH2
Chorionic somatomammotropin hormone 2

Protein Summary
Description
Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated d ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336844
  • ENSP00000338816
  • ENSG00000213218
  • ENST00000345366
  • ENSP00000308396
  • ENST00000392886
  • ENSP00000376623

Symbol
  • PL
  • CSB
  • CS-2
  • GHB1
  • hCS-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.66
cell line
0.49
disease
0.4
tissue
0.4
phenotype
0.37


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 925.44   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 925.44   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
16.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
16.2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P0DML3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (122)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
PI3K-Akt signaling pathway
KEGG
JAK-STAT signaling pathway
KEGG
Neuroactive ligand-receptor interaction
KEGG
Cytokine-cytokine receptor interaction
Name
Explore in Pharos
Explore in Source
PI3K-Akt signaling pathway
JAK-STAT signaling pathway
Neuroactive ligand-receptor interaction
Cytokine-cytokine receptor interaction
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (108)
1 – 10 of 108
CSH1
Tbio
Novelty: 0.00100314
p_int: 0.999999993
p_ni: 6e-9
p_wrong: 1e-9
Score: 0.992
Data Source: BioPlex,STRINGDB
SCG5
Tbio
Novelty: 0.00379377
p_int: 0.999957565
p_ni: 0.000042435
Score: 0.712
Data Source: BioPlex,STRINGDB
SOST
Tclin
Novelty: 0.0009273
p_int: 0.999809456
p_ni: 0.000190544
Score: 0.187
Data Source: BioPlex,STRINGDB
GHR
Tclin
Novelty: 0.00105635
Score: 0.916
Data Source: STRINGDB
PRL
Tbio
Novelty: 0.0000905
Score: 0.914
Data Source: STRINGDB
PRLR
Tbio
Novelty: 0.00161982
Score: 0.888
Data Source: STRINGDB
LEP
Tbio
Novelty: 0.00005295
Score: 0.887
Data Source: STRINGDB
GH1
Tbio
Novelty: 0.00072523
Score: 0.852
Data Source: STRINGDB
EPO
Tbio
Novelty: 0.00013701
Score: 0.838
Data Source: STRINGDB
CSF3
Tbio
Novelty: 0.00011283
Score: 0.804
Data Source: STRINGDB
Publication Statistics
PubMed Score  925.44

PubMed score by year
PubTator Score  1384.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer