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Tbio
CSH1
Chorionic somatomammotropin hormone 1

Protein Summary
Description
Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins fo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316193
  • ENSP00000316416
  • ENSG00000136488

Symbol
  • PL
  • CSA
  • CS-1
  • CSMT
  • GHB3
  • hCS-1
  • hCS-A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.6
protein domain
0.58
disease perturbation
0.56
cell type or tissue
0.52
disease
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 894.83   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 393   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 894.83   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 393   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (128)
1 – 10 of 128
GH1
Tbio
Novelty:  0.00072523
p_int:  1
Score:  0.976
Data Source:  BioPlex,Reactome,STRINGDB
CSH2
Tbio
Novelty:  0.0009706
p_int:  0.999999993
p_ni:  6e-9
p_wrong:  1e-9
Score:  0.992
Data Source:  BioPlex,STRINGDB
ISCA1
Tbio
Novelty:  0.01288069
p_int:  0.986055874
p_ni:  0.013618
p_wrong:  0.000326126
Score:  0.187
Data Source:  BioPlex,STRINGDB
PRLR
Tbio
Novelty:  0.00161982
Score:  0.981
Data Source:  Reactome,STRINGDB
GHR
Tclin
Novelty:  0.00105635
Score:  0.959
Data Source:  STRINGDB
PRL
Tbio
Novelty:  0.0000905
Score:  0.957
Data Source:  Reactome,STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
Score:  0.939
Data Source:  Reactome,STRINGDB
STAT5B
Tchem
Family:  TF
Novelty:  0.00074178
Score:  0.938
Data Source:  Reactome,STRINGDB
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.933
Data Source:  Reactome,STRINGDB
IRS1
Tchem
Novelty:  0.00048281
Score:  0.915
Data Source:  STRINGDB
Pathways (16)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Growth hormone receptor signaling
Reactome
Immune System
Reactome
Prolactin receptor signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Growth hormone receptor signaling
Immune System
Prolactin receptor signaling
Gene Ontology Terms (17)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
7
8
10
97.7
IGF-1 measurement
1
3
3
97.6
BMI-adjusted hip circumference
3
9
11
93.5
appendicular lean mass
2
2
4
91.1
hematocrit
2
2
2
88.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
10
97.7
IGF-1 measurement
3
97.6
BMI-adjusted hip circumference
11
93.5
appendicular lean mass
4
91.1
hematocrit
2
88.5
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:95707
14599
Rat
RGD:2686
24391
Dog
growth hormone
403795
Horse
growth hormone 1
100034180
Cow
growth hormone 1
280804
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
growth hormone
Horse
growth hormone 1
Cow
growth hormone 1
Publication Statistics
PubMed Score 894.83
PubMed score by year
PubTator Score 344.01
PubTator score by year