Tbio CSH1 Chorionic somatomammotropin hormone 1

Protein Summary

Description

Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P0DML2
• P01243
• Q0VDB1
• Q14407
• Choriomammotropin

Gene Name

• CSH1

Ensembl ID

• ENST00000316193
• ENSP00000316416
• ENSG00000136488

Symbol

• PL
• CSA
• CS-1
• CSMT
• GHB3
• hCS-1
• hCS-A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.6
protein domain	0.58
disease perturbation	0.56
cell type or tissue	0.52
disease	0.52

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Peptide Hormone / Chorionic Somatomammotropin Hormone 1

Protein / Signaling Molecule / Growth Factor / Chorionic Somatomammotropin Hormone 1

DTO Classes

Protein / Signaling / Growth Factor / Chorionic Somatomammotropin Hormone 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 943.82   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 393   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 943.82   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 393   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0