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Tclin
PGA5
Pepsin A-5

Protein Summary
Description
Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312403
  • ENSP00000309542
  • ENSG00000256713

Symbol
  • Pg5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.67
PubMedID
0.67
protein domain
0.58
cellular component
0.56
tissue sample
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.97   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.97   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 18
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
sucralfate
no chemical structure image available
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Surfactant metabolism
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Surfactant metabolism
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (20)
1 – 10 of 20
SFTPB
Tbio
Novelty: 0.00138979
Score: 0.904
Data Source: STRINGDB
SFTPC
Tbio
Novelty: 0.00174879
Score: 0.9
Data Source: STRINGDB
PGA4
Tbio
Family: Enzyme
Novelty: 0.04303786
Score: 0.862
Data Source: STRINGDB
PGA3
Tbio
Family: Enzyme
Novelty: 0.03312865
Score: 0.808
Data Source: STRINGDB
GLO1
Tchem
Family: Enzyme
Novelty: 0.00268656
Score: 0.751
Data Source: STRINGDB
CCHCR1
Tbio
Novelty: 0.01110278
Score: 0.67
Data Source: STRINGDB
LGALS4
Tchem
Novelty: 0.00036714
Score: 0.669
Data Source: STRINGDB
CTRB2
Tdark
Family: Enzyme
Novelty: 0.03058532
Score: 0.641
Data Source: STRINGDB
CTRB1
Tchem
Family: Enzyme
Novelty: 0.01227574
Score: 0.573
Data Source: STRINGDB
PRSS2
Tchem
Family: Enzyme
Novelty: 0.00958976
Score: 0.557
Data Source: STRINGDB
Publication Statistics
PubMed Score  89.97

PubMed score by year
PubTator Score  94.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer