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Tbio
PGA3
Pepsin A-3

Protein Summary
Description
Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.51
tissue
0.51
disease
0.48
cell line
0.42
virus perturbation
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.47   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.47   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Surfactant metabolism
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Surfactant metabolism
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (15)
1 – 10 of 15
PGA4
Tbio
Family: Enzyme
Novelty: 0.06491002
Score: 0.96
Data Source: STRINGDB
SFTPB
Tbio
Novelty: 0.00163925
Score: 0.904
Data Source: STRINGDB
SFTPC
Tbio
Novelty: 0.00154396
Score: 0.9
Data Source: STRINGDB
PGA5
Tclin
Family: Enzyme
Novelty: 0.00810507
Score: 0.808
Data Source: STRINGDB
CTRB2
Tdark
Family: Enzyme
Novelty: 0.20557479
Score: 0.708
Data Source: STRINGDB
CTRB1
Tchem
Family: Enzyme
Novelty: 0.01637745
Score: 0.67
Data Source: STRINGDB
PRSS2
Tchem
Family: Enzyme
Novelty: 0.00959404
Score: 0.66
Data Source: STRINGDB
PRSS3P2
Tdark
Family: Enzyme
Novelty: 0.00959404
Score: 0.66
Data Source: STRINGDB
PRSS1
Tclin
Family: Enzyme
Novelty: 0.00157396
Score: 0.592
Data Source: STRINGDB
PRSS3
Tchem
Family: Enzyme
Novelty: 0.00360444
Score: 0.589
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.47

PubMed score by year
PubTator Score  19.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer