Protein Summary
Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription fac ...more
- ENST00000339647
- ENSP00000344818
- ENSG00000150991
- ENST00000536769
- ENSP00000441543
- HMG20
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
disease perturbation | 1 | ||
hub protein | 1 | ||
virus perturbation | 1 | ||
transcription factor binding site profile | 0.99 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 347.83 (req: < 5)
Gene RIFs: 68 (req: <= 3)
Antibodies: 189 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 347.83 (req: >= 5)
Gene RIFs: 68 (req: > 3)
Antibodies: 189 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 48
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (1428)
Nearest Tclin Targets
Pathways (327)
Reactome (323)
KEGG (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | ABC transporter disorders | ||||
Reactome | ABC-family proteins mediated transport | ||||
Reactome | APC-Cdc20 mediated degradation of Nek2A | ||||
Reactome | APC/C-mediated degradation of cell cycle proteins | ||||
Reactome | APC/C:Cdc20 mediated degradation of Cyclin B | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
ABC transporter disorders | ||||
ABC-family proteins mediated transport | ||||
APC-Cdc20 mediated degradation of Nek2A | ||||
APC/C-mediated degradation of cell cycle proteins | ||||
APC/C:Cdc20 mediated degradation of Cyclin B | ||||
Viral Interactions (0)
Gene Ontology Terms (62)
Functions (4)
Components (14)
Processes (44)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (26)
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 9 | 15 | 23 | 98.5 | |||||
apolipoprotein A 1 measurement | 2 | 6 | 6 | 97.3 | |||||
sleep duration | 2 | 4 | 4 | 89.8 | |||||
5 | 4 | 5 | 1.1 | 89.7 | |||||
low density lipoprotein cholesterol measurement | 4 | 4 | 4 | 88 | |||||
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 23 | 98.5 | |||||
apolipoprotein A 1 measurement | 6 | 97.3 | |||||
sleep duration | 4 | 89.8 | |||||
5 | 1.1 | 89.7 | |||||
low density lipoprotein cholesterol measurement | 4 | 88 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ubiquitin C | 467151 | ||||||
Macaque | ubiquitin C | 712934 | ||||||
Mouse | MGI:98889 | 22190 | ||||||
Rat | RGD:621244 | 50522 | ||||||
Pig | ubiquitin C | 396966 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ubiquitin C | |||||
Macaque | ubiquitin C | |||||
Mouse | ||||||
Rat | ||||||
Pig | ubiquitin C | |||||
Publication Statistics
PubMed Score 347.83
PubMed score by year
PubTator Score 137.69
PubTator score by year
Related Publications
Text Mined References (218)
GeneRif Annotations (68)
Items per page:
0 of 0
PMID | Year | Title |
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