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Tbio
UBC
Polyubiquitin-C

Protein Summary
Description
Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription fac ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease perturbation
1
hub protein
1
virus perturbation
1
transcription factor binding site profile
0.99


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 344.55   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 344.55   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin C
467151
Macaque
ubiquitin C
712934
Mouse
MGI:98889
22190
Rat
RGD:621244
50522
Pig
ubiquitin C
396966
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin C
Macaque
ubiquitin C
Mouse
Rat
Pig
ubiquitin C
Protein Structure (206 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P0CG48-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 206
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (327)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 323
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC-Cdc20 mediated degradation of Nek2A
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Cyclin B
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC-Cdc20 mediated degradation of Nek2A
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
Gene Ontology Terms (62)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (1428)
1 – 10 of 1428
RHOT2
Tbio
Family: Enzyme
Novelty: 0.01712732
p_int: 1
Score: 0.419
Data Source: BioPlex,STRINGDB
FAAP20
Tbio
Novelty: 0.15112645
Score: 0.999
Data Source: STRINGDB
RAD18
Tbio
Family: Enzyme
Novelty: 0.00519213
Score: 0.999
Data Source: STRINGDB
UBE2V2
Tbio
Novelty: 0.01112479
Score: 0.999
Data Source: STRINGDB
UBE2K
Tbio
Novelty: 0.00214955
Score: 0.999
Data Source: STRINGDB
TAB2
Tbio
Family: Enzyme
Novelty: 0.00635786
Score: 0.999
Data Source: STRINGDB
UBE2S
Tbio
Novelty: 0.00363304
Score: 0.999
Data Source: STRINGDB
UBE2N
Tbio
Novelty: 0.00620946
Score: 0.999
Data Source: STRINGDB
CDC20
Tbio
Novelty: 0.00197887
Score: 0.999
Data Source: STRINGDB
UBE2D1
Tbio
Novelty: 0.00865867
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  344.55

PubMed score by year
PubTator Score  137.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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