Tbio UBC Polyubiquitin-C

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / Polyubiquitin-c

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / Polyubiquitin-c

Protein Summary

Description

Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. [provided by RefSeq, Aug 2010]

Uniprot Accession IDs

• P0CG48
• P02248
• P02249
• P02250
• P62988
• Q29120
• Q6LBL4
• Q6LDU5
• Q8WYN8
• Q91887
• Q91888
• Q9BWD6
• Q9BX98
• Q9UEF2
• Q9UEG1
• Q9UEK8
• Q9UPK7

Gene Name

• UBC

Ensembl ID

• ENST00000339647
• ENSP00000344818
• ENSG00000150991
• ENST00000536769
• ENSP00000441543

Symbol

• HMG20

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
disease perturbation	1
hub protein	1
virus perturbation	1
transcription factor binding site profile	0.99

Related Tools

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ARCHS4

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 344.55   (req: < 5)

Gene RIFs: 68   (req: <= 3)

Antibodies: 189   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 344.55   (req: >= 5)

Gene RIFs: 68   (req: > 3)

Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ubiquitin C		467151
Macaque	ubiquitin C		712934
Mouse	ubiquitin C	MGI:98889	22190
Rat	ubiquitin C	RGD:621244	50522
Pig	ubiquitin C		396966

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ubiquitin C
Macaque	ubiquitin C
Mouse	ubiquitin C
Rat	ubiquitin C
Pig	ubiquitin C

Protein Structure (206 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P0CG48-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 206

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (327)

Reactome (323)

KEGG (1)

WikiPathways (3)

ABC transporter disorders (R-HSA-5619084)

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Find Similar Targets

Items per page:

5

1 – 5 of 323

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ABC transporter disorders	78 targets	R-HSA-5619084
Reactome	ABC-family proteins mediated transport	104 targets	R-HSA-382556
Reactome	APC-Cdc20 mediated degradation of Nek2A	25 targets	R-HSA-179409
Reactome	APC/C-mediated degradation of cell cycle proteins	87 targets	R-HSA-174143
Reactome	APC/C:Cdc20 mediated degradation of Cyclin B	23 targets	R-HSA-174048

Name	Explore in Pharos	Explore in Source
ABC transporter disorders	78 targets	R-HSA-5619084
ABC-family proteins mediated transport	104 targets	R-HSA-382556
APC-Cdc20 mediated degradation of Nek2A	25 targets	R-HSA-179409
APC/C-mediated degradation of cell cycle proteins	87 targets	R-HSA-174143
APC/C:Cdc20 mediated degradation of Cyclin B	23 targets	R-HSA-174048

Gene Ontology Terms (62)

Functions (4)

Components (14)

Processes (44)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
protease binding	Inferred from Physical Interaction (IPI)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
protein tag	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ubiquitin protein ligase binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (1428)

Explore Interacting Targets

1 – 10 of 1428

• See Interactions on String-DB

RHOT2

Tbio

Family: Enzyme

Novelty: 0.01712732

p_int: 1

Score: 0.419

Data Source: BioPlex,STRINGDB

FAAP20

Tbio

Novelty: 0.15112645

Score: 0.999

Data Source: STRINGDB

RAD18

Tbio

Family: Enzyme

Novelty: 0.00519213

Score: 0.999

Data Source: STRINGDB

UBE2V2

Tbio

Novelty: 0.01112479

Score: 0.999

Data Source: STRINGDB

UBE2K

Tbio

Novelty: 0.00214955

Score: 0.999

Data Source: STRINGDB

TAB2

Tbio

Family: Enzyme

Novelty: 0.00635786

Score: 0.999

Data Source: STRINGDB

UBE2S

Tbio

Novelty: 0.00363304

Score: 0.999

Data Source: STRINGDB

UBE2N

Tbio

Novelty: 0.00620946

Score: 0.999

Data Source: STRINGDB

CDC20

Tbio

Novelty: 0.00197887

Score: 0.999

Data Source: STRINGDB

UBE2D1

Tbio

Novelty: 0.00865867

Score: 0.998

Data Source: STRINGDB

Publication Statistics

PubMed Score  344.55

PubMed score by year

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PubTator Score  137.69

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

3D-structure
ADP-ribosylation
Complete proteome
Cytoplasm
Direct protein sequencing
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Repeat

MGI Phenotype Find Similar Targets

cellular phenotype
embryo phenotype
growth/size/body region phenotype
hematopoietic system phenotype
liver/biliary system phenotype
mortality/aging