Protein Summary
Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription fac ...more
- ENST00000302182
- ENSP00000304697
- ENSG00000170315
- ENST00000395837
- ENSP00000379178
- ENST00000395839
- ENSP00000379180
- ENST00000614404
- ENSP00000478771
- HEL-S-50
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
hub protein | 1 | ||
transcription factor binding site profile | 0.98 | ||
interacting protein | 0.97 | ||
cellular component | 0.95 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 156.39 (req: < 5)
Gene RIFs: 26 (req: <= 3)
Antibodies: 608 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 156.39 (req: >= 5)
Gene RIFs: 26 (req: > 3)
Antibodies: 608 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 61
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (1428)
TNFRSF1A
Novelty: 0.00037847
p_int: 0.999998581
p_ni: 0.000001419
Score: 0.912
Data Source: BioPlex,STRINGDB
RNF126
Family: Enzyme
Novelty: 0.08123801
p_int: 0.999996673
p_ni: 0.000003327
Score: 0.932
Data Source: BioPlex,STRINGDB
EPN3
Novelty: 0.12685855
p_int: 0.999992406
p_ni: 0.000007594
Score: 0.418
Data Source: BioPlex,STRINGDB
CTLA4
Novelty: 0.00012781
p_int: 0.999983327
p_ni: 0.000011709
p_wrong: 0.000004965
Data Source: BioPlex
UBE2E3
Novelty: 0.03477232
p_int: 0.999975722
p_ni: 0.000024278
Score: 0.946
Data Source: BioPlex,STRINGDB
SCN1B
Family: IC
Novelty: 0.00910273
p_int: 0.999971749
p_ni: 0.000027894
p_wrong: 3.58e-7
Data Source: BioPlex
TMEM31
Novelty: 0.65381391
p_int: 0.999939253
p_ni: 0.000060565
p_wrong: 1.82e-7
Data Source: BioPlex
OR2G6
Family: oGPCR
p_int: 0.999912792
p_ni: 0.000079655
p_wrong: 0.000007554
Data Source: BioPlex
RNF19B
Family: Enzyme
Novelty: 0.20054824
p_int: 0.999897162
p_ni: 0.000102838
Score: 0.92
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (336)
Reactome (328)
KEGG (4)
PathwayCommons (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | ABC transporter disorders | ||||
Reactome | ABC-family proteins mediated transport | ||||
Reactome | APC-Cdc20 mediated degradation of Nek2A | ||||
Reactome | APC/C-mediated degradation of cell cycle proteins | ||||
Reactome | APC/C:Cdc20 mediated degradation of Cyclin B | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
ABC transporter disorders | ||||
ABC-family proteins mediated transport | ||||
APC-Cdc20 mediated degradation of Nek2A | ||||
APC/C-mediated degradation of cell cycle proteins | ||||
APC/C:Cdc20 mediated degradation of Cyclin B | ||||
Viral Interactions (0)
Gene Ontology Terms (78)
Functions (2)
Components (17)
Processes (59)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
risk-taking behaviour | 2 | 2 | 2 | 63 | |||||
smoking status measurement | 2 | 1 | 2 | 40.7 | |||||
mathematical ability | 1 | 1 | 1 | 28.1 | |||||
self reported educational attainment | 1 | 1 | 1 | 21.5 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
risk-taking behaviour | 2 | 63 | |||||
smoking status measurement | 2 | 40.7 | |||||
mathematical ability | 1 | 28.1 | |||||
self reported educational attainment | 1 | 21.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | ubiquitin B | 468372 | ||||||
Macaque | ubiquitin B | 696110 | ||||||
Mouse | MGI:98888 | 22187 | ||||||
Dog | ubiquitin B | VGNC:49664 | 479513 | |||||
Horse | ubiquitin B [Source:HGNC Symbol;Acc:HGNC:12463] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | ubiquitin B | |||||
Macaque | ubiquitin B | |||||
Mouse | ||||||
Dog | ubiquitin B | |||||
Horse | ubiquitin B [Source:HGNC Symbol;Acc:HGNC:12463] | |||||
Publication Statistics
PubMed Score 156.39
PubMed score by year
PubTator Score 36.35
PubTator score by year
Related Publications
Text Mined References (165)
GeneRif Annotations (26)
Items per page:
0 of 0
PMID | Year | Title |
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