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Tbio
UBB
Polyubiquitin-B

Protein Summary
Description
Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription fac ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
transcription factor binding site profile
0.98
interacting protein
0.97
cellular component
0.95


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.06   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 608   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.06   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 608   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 61
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin B
468372
Macaque
ubiquitin B
696110
Mouse
MGI:98888
22187
Dog
ubiquitin B
VGNC:49664
479513
Horse
ubiquitin B [Source:HGNC Symbol;Acc:HGNC:12463]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin B
Macaque
ubiquitin B
Mouse
Dog
ubiquitin B
Horse
ubiquitin B [Source:HGNC Symbol;Acc:HGNC:12463]
Protein Structure (117 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P0CG47-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 117
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (336)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 328
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC-Cdc20 mediated degradation of Nek2A
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Cyclin B
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC-Cdc20 mediated degradation of Nek2A
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
Gene Ontology Terms (78)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (1428)
1 – 10 of 1428
TNFRSF1A
Tchem
Novelty: 0.00037847
p_int: 0.999998581
p_ni: 0.000001419
Score: 0.912
Data Source: BioPlex,STRINGDB
RNF126
Tbio
Family: Enzyme
Novelty: 0.08123801
p_int: 0.999996673
p_ni: 0.000003327
Score: 0.932
Data Source: BioPlex,STRINGDB
EPN3
Tbio
Novelty: 0.12685855
p_int: 0.999992406
p_ni: 0.000007594
Score: 0.418
Data Source: BioPlex,STRINGDB
CTLA4
Tclin
Novelty: 0.00012781
p_int: 0.999983327
p_ni: 0.000011709
p_wrong: 0.000004965
Data Source: BioPlex
UBE2E3
Tbio
Novelty: 0.03477232
p_int: 0.999975722
p_ni: 0.000024278
Score: 0.946
Data Source: BioPlex,STRINGDB
SCN1B
Tbio
Family: IC
Novelty: 0.00910273
p_int: 0.999971749
p_ni: 0.000027894
p_wrong: 3.58e-7
Data Source: BioPlex
TMEM31
Tdark
Novelty: 0.65381391
p_int: 0.999939253
p_ni: 0.000060565
p_wrong: 1.82e-7
Data Source: BioPlex
OR2G6
Tdark
Family: oGPCR
p_int: 0.999912792
p_ni: 0.000079655
p_wrong: 0.000007554
Data Source: BioPlex
LTBR
Tbio
Novelty: 0.003823
p_int: 0.999908455
p_ni: 0.000091545
Data Source: BioPlex
RNF19B
Tbio
Family: Enzyme
Novelty: 0.20054824
p_int: 0.999897162
p_ni: 0.000102838
Score: 0.92
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  147.06

PubMed score by year
PubTator Score  36.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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