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Tdark
SP9
Transcription factor Sp9

Protein Summary
Description
Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394967
  • ENSP00000378418
  • ENSG00000217236

Symbol
  • ZNF990
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.78
cell type or tissue
0.73
transcription factor binding site profile
0.65
histone modification site profile
0.57
tissue sample
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.21   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 20   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.21   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 20   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (14)
ACRV1
Tbio
Novelty:  0.00291978
Score:  0.86
Data Source:  STRINGDB
MMP28
Tbio
Family:  Enzyme
Novelty:  0.01679444
Score:  0.805
Data Source:  STRINGDB
LIPN
Tbio
Family:  Enzyme
Novelty:  0.00135912
Score:  0.789
Data Source:  STRINGDB
MMP19
Tbio
Family:  Enzyme
Novelty:  0.01407961
Score:  0.63
Data Source:  STRINGDB
PCSK5
Tchem
Family:  Enzyme
Novelty:  0.00070772
Score:  0.565
Data Source:  STRINGDB
LRP5
Tbio
Novelty:  0.00089807
Score:  0.559
Data Source:  STRINGDB
TMEM176B
Tbio
Novelty:  0.02452255
Score:  0.491
Data Source:  STRINGDB
ETAA1
Tbio
Novelty:  0.07555913
Score:  0.485
Data Source:  STRINGDB
NDUFB8
Tclin
Family:  Enzyme
Novelty:  0.019021
Score:  0.455
Data Source:  STRINGDB
ADORA2A
Tclin
Family:  GPCR
Novelty:  0.00054557
Score:  0.42
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
grip strength measurement
2
1
2
56
body height
1
1
1
45.7
triglyceride measurement
2
2
2
43.9
physical activity measurement
1
1
1
29
HbA1c measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
grip strength measurement
2
56
body height
1
45.7
triglyceride measurement
2
43.9
physical activity measurement
1
29
HbA1c measurement
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3574660
381373
Rat
RGD:1559457
366078
Cow
Sp9 transcription factor
VGNC:35159
517257
Opossum
Sp9 transcription factor
100018680
Anole lizard
Sp9 transcription factor
100557316
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
Sp9 transcription factor
Opossum
Sp9 transcription factor
Anole lizard
Sp9 transcription factor
Publication Statistics
PubMed Score 202.21
PubMed score by year
PubTator Score 73.82
PubTator score by year
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Related Publications
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PMID
Year
Title