Protein Summary
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). May be involved in cell migration.
- ENST00000419165
- ENSP00000456121
- ENSG00000158427
- ENST00000436583
- ENSP00000455771
- ENST00000540220
- ENSP00000455371
- ENST00000569577
- ENSP00000457057
- TMSL8
- TMSNB
- TMSB15A
- Tbeta15b
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
tissue | 0.65 | ||
histone modification site profile | 0.61 | ||
virus perturbation | 0.55 | ||
transcription factor perturbation | 0.47 | ||
tissue sample | 0.45 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.78 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 9 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.78 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 9 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0