You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GSTT2B
Glutathione S-transferase theta-2B

Protein Summary
Description
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity. The protein encoded by this gene, glutathione S-transferase (GST) theta 2B (GSTT2B), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2B gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290765
  • ENSP00000290765
  • ENSG00000133433
  • ENST00000616938
  • ENSP00000478389
  • ENSG00000278695

Symbol
  • GSTT2
  • GSTT2P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.61
protein domain
0.58
tissue sample
0.56
pathway
0.53
metabolite
0.46


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.85   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.85   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (48)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Glutathione conjugation
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Glutathione conjugation
Metabolism
Phase II - Conjugation of compounds
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (87)
1 – 10 of 87
SPDL1
Tbio
Novelty: 0.01399644
p_int: 0.999998319
p_ni: 0.000001681
Score: 0.187
Data Source: BioPlex,STRINGDB
NMD3
Tbio
Novelty: 0.03505289
p_int: 0.999969244
p_ni: 0.000030756
Score: 0.28
Data Source: BioPlex,STRINGDB
CARD9
Tbio
Family: Enzyme
Novelty: 0.00547101
p_int: 0.999954629
p_ni: 0.000045345
p_wrong: 2.6e-8
Score: 0.807
Data Source: BioPlex,STRINGDB
SIRT2
Tchem
Family: Epigenetic
Novelty: 0.00093962
p_int: 0.971570974
p_ni: 0.028428895
p_wrong: 1.31e-7
Score: 0.201
Data Source: BioPlex,STRINGDB
GSTP1
Tchem
Family: Enzyme
Novelty: 0.00045452
Score: 0.923
Data Source: STRINGDB
GGH
Tchem
Family: Enzyme
Novelty: 0.00258239
Score: 0.904
Data Source: STRINGDB
GSTA4
Tbio
Family: Enzyme
Novelty: 0.01099229
Score: 0.885
Data Source: STRINGDB
GSTM2
Tchem
Family: Enzyme
Novelty: 0.00334543
Score: 0.885
Data Source: STRINGDB
GSTO1
Tchem
Family: Enzyme
Novelty: 0.00800915
Score: 0.878
Data Source: STRINGDB
GSTM3
Tbio
Family: Enzyme
Novelty: 0.0078192
Score: 0.878
Data Source: STRINGDB
Publication Statistics
PubMed Score  42.85

PubMed score by year
PubTator Score  3.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer