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Tbio
P0CG13
Chromosome transmission fidelity protein 8 homolog

Protein Summary
Description
Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression. This gene encodes a short protein that forms part of the Ctf18 replication factor C (RFC) complex that occurs in both yeast and mammals. The heteroheptameric RFC complex plays a role in sister chromatid cohesion and may lo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398235
  • ENSP00000381290
  • ENSG00000168802
  • ENST00000448552
  • ENSP00000408367

Symbol
  • CTF8
  • CTF8
  • DERPC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
gene perturbation
0.81
tissue sample
0.71
transcription factor binding site profile
0.65
microRNA
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.44   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.44   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
DSCC1
Tbio
Novelty:  0.04747149
p_int:  0.999999993
p_ni:  6e-9
p_wrong:  1e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
FKBP9
Tbio
Family:  Enzyme
Novelty:  0.16472204
p_int:  0.999999891
p_ni:  1.08e-7
p_wrong:  2e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
RFC5
Tbio
Novelty:  0.03987481
p_int:  0.99999882
p_ni:  0.000001177
p_wrong:  2e-9
Score:  0.995
Data Source:  BioPlex,STRINGDB
RFC4
Tbio
Novelty:  0.03232586
p_int:  0.999996538
p_ni:  1.42e-7
p_wrong:  0.00000332
Score:  0.993
Data Source:  BioPlex,STRINGDB
IL36A
Tbio
Novelty:  0.03569425
p_int:  0.99994968
p_ni:  0.000045906
p_wrong:  0.000004414
Score:  0.534
Data Source:  BioPlex,STRINGDB
PPIE
Tbio
Family:  Enzyme
Novelty:  0.01586411
p_int:  0.999186266
p_ni:  0.000802191
p_wrong:  0.000011543
Score:  0.187
Data Source:  BioPlex,STRINGDB
CHTF18
Tbio
Novelty:  0.02470494
Score:  0.997
Data Source:  STRINGDB
RFC3
Tbio
Novelty:  0.02712951
Score:  0.983
Data Source:  STRINGDB
RFC2
Tbio
Novelty:  0.02088405
Score:  0.966
Data Source:  STRINGDB
ESCO1
Tbio
Family:  Enzyme
Novelty:  0.01447283
Score:  0.777
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
2
42.3
body mass index
1
1
2
42.3
diastolic blood pressure
1
1
2
12.2
diastolic blood pressure
1
1
2
12.2
heel bone mineral density
1
1
2
10.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
42.3
body mass index
2
42.3
diastolic blood pressure
2
12.2
diastolic blood pressure
2
12.2
heel bone mineral density
2
10.6
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 8.44
PubMed score by year
PubTator Score 4.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title