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Tdark
CHTF8
Chromosome transmission fidelity protein 8 homolog isoform 2

Protein Summary
Description
Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed. This gene encodes a short protein that forms part of the Ctf18 replication factor C (RFC) complex that occurs in both yeast and mammals. The heteroheptameric RFC complex plays a role in sister chromatid cohesion and may load the replication clamp PCNA (proliferating cell nuclear antigen) onto DNA during DNA replication and repair. This gene is ubiquitously expressed and has been shown to have reduced expression in renal and prostate tumors. Alternatively spliced transcript variants have been described. This gene has a pseudogene on chromosome X. [provided by RefSeq, Oct 2018]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306585
  • ENSP00000305687
  • ENSG00000168802

Symbol
  • DERPC
  • CTF8
  • DERPC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.44   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.44   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
2
42.3
body mass index
1
1
2
42.3
diastolic blood pressure
1
1
2
12.2
diastolic blood pressure
1
1
2
12.2
heel bone mineral density
1
1
2
10.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
42.3
body mass index
2
42.3
diastolic blood pressure
2
12.2
diastolic blood pressure
2
12.2
heel bone mineral density
2
10.6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P0CG12-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (31)
1 – 10 of 31
KCTD12
Tchem
Novelty:  0.0386637
p_int:  0.999998982
p_ni:  0.000001017
p_wrong:  1e-9
Data Source:  BioPlex
CHTF18
Tbio
Novelty:  0.02470494
p_int:  0.99772344
p_ni:  0.000211725
p_wrong:  0.002064835
Score:  0.997
Data Source:  BioPlex,STRINGDB
DSCC1
Tbio
Novelty:  0.04747149
Score:  0.996
Data Source:  STRINGDB
RFC5
Tbio
Novelty:  0.03987481
Score:  0.995
Data Source:  STRINGDB
RFC4
Tbio
Novelty:  0.03232586
Score:  0.993
Data Source:  STRINGDB
RFC3
Tbio
Novelty:  0.02712951
Score:  0.983
Data Source:  STRINGDB
RFC2
Tbio
Novelty:  0.02088405
Score:  0.966
Data Source:  STRINGDB
ESCO1
Tbio
Family:  Enzyme
Novelty:  0.01447283
Score:  0.777
Data Source:  STRINGDB
ESCO2
Tbio
Family:  Enzyme
Novelty:  0.0203615
Score:  0.759
Data Source:  STRINGDB
WAPL
Tbio
Novelty:  0.01598061
Score:  0.744
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.44

PubMed score by year
PubTator Score  4.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer