Tbio GPR89B Golgi pH regulator B

Protein Summary

Description

Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. GPR89A is a nearly identical copy of the GPR89B gene (MIM 612806).[supplied by OMIM, Jun 2009]

Uniprot Accession IDs

• P0CG08
• A6NKF9
• A6NN37
• B2RUV3
• B3KMN3
• Q53FQ9
• Q5T2V8
• Q5T5P5
• Q659E2
• Q6NVY5
• Q9P0S4
• Q9Y302

Gene Name

• GPR89B

Ensembl ID

• ENST00000314163
• ENSP00000358233
• ENSG00000188092

Symbol

• GPHRB
• GPR89C
• GPHR
• GPR89
• SH120
• GPR89B
• UNQ192

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.73
tissue	0.66
small molecule perturbation	0.51
cellular component	0.48
transcription factor	0.43

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Golgi Ph Regulator B

DTO Classes

Protein / Ion Channel / Golgi Ph Regulator Family / Golgi Ph Regulator B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.05   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 51   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.05   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0