Tbio P0CAP2 DNA-directed RNA polymerase II subunit GRINL1A

Protein Summary

Description

Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. This gene encodes a subunit of a specific form of RNA polymerase II termed Pol II(G). The encoded protein may act as a negative regulator of transcriptional activation by the Mediator complex. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 4. Readthrough transcription between this gene and the neighboring upstream gene MYZAP (myocardial zonula adherens protein) is represented with GeneID 145781. [provided by RefSeq, Oct 2013]

Uniprot Accession IDs

• P0CAP2
• Q6EER8
• Q6EES2
• Q6EEV3
• Q6EF00
• Q6EF01
• Q6EF02
• Q6EF46
• Q6EFN8
• Q6EM48
• Q6K046
• Q6K050
• Q6K051
• Q6ZQZ3
• Q8NC58
• Q8NCF3
• Q96DI5
• Q96JB7
• Q96NF5
• Q9Y3V6

Gene Name

• POLR2M

Ensembl ID

• ENST00000299638
• ENSP00000299638
• ENSG00000255529
• ENST00000380557
• ENSP00000369930
• ENST00000482852
• ENSP00000432615

Symbol

• GRINL1A
• GCOM1
• Gdown
• Gdown1
• GRINL1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.28   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 88   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.28   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0