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Tdark
MYZAP
Myocardial zonula adherens protein

Protein Summary
Description
Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity). This gene encodes a protein that is abundantly expressed in cardiac tissue. The encoded protein localizes to intercalated discs in cardiomyocytes and functions as an activator of Rho-dependent serum-response factor signaling. Alternative splicing results in multiple transcript variants. Readthrough transcription also exists between this gene and the neighboring downstream gene POLR2M (polymerase (RNA) II (DNA directed) polypeptide M) and is represented with GeneID: 145781. [provided by RefSeq, Mar 2014]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.92
disease perturbation
0.9
transcription factor binding site profile
0.89
cellular component
0.81
kinase perturbation
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.03   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.03   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (13)
Q6EEV4
Tbio
Family:  Enzyme
Novelty:  0.11413088
Score:  0.765
Data Source:  STRINGDB
P0CAP2
Tbio
Family:  Enzyme
Novelty:  0.11413088
Score:  0.765
Data Source:  STRINGDB
PKP2
Tbio
Novelty:  0.00493803
Score:  0.753
Data Source:  STRINGDB
DSP
Tbio
Novelty:  0.00178018
Score:  0.686
Data Source:  STRINGDB
TCP11L1
Tdark
Novelty:  1.5011461
Score:  0.611
Data Source:  STRINGDB
TJP1
Tbio
Novelty:  0.00040365
Score:  0.534
Data Source:  STRINGDB
DTNBP1
Tbio
Novelty:  0.00341619
Score:  0.532
Data Source:  STRINGDB
CRLF3
Tbio
Novelty:  0.17318857
Score:  0.496
Data Source:  STRINGDB
STRN
Tbio
Novelty:  0.01025814
Score:  0.487
Data Source:  STRINGDB
BTF3L4
Tdark
Novelty:  0.61724061
Score:  0.471
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
2
2
5.5
68.5
1
1
0
1.4
42.3
serum gamma-glutamyl transferase measurement
1
1
1
31.4
sleep duration
1
1
1
3.5
high density lipoprotein cholesterol measurement
1
1
1
3.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
5.5
68.5
0
1.4
42.3
serum gamma-glutamyl transferase measurement
1
31.4
sleep duration
1
3.5
high density lipoprotein cholesterol measurement
1
3.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 20.03
PubMed score by year
PubTator Score 4.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title