Tbio JMJD7 JmjC domain-containing protein 7

Protein Summary

Description

This gene encodes a highly conserved protein with a JmjC domain, which are part of the cupin metalloenzyme superfamily. JmjC proteins may function as 2-oxoglutarate-Fe(II)-dependent dioxygenases. Most tissues also express read-through transcripts from this gene into the downstream phospholipase A2, group IVB (cytosolic) gene, some of which may encode fusion proteins combining the N-terminus of this protein with the phospholipase A2, group IVB protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P0C870
• A5D6V5
• O95712
• Q59GF9
• Q8TB10
• Q9UKV7

Gene Name

• JMJD7

Ensembl ID

• ENST00000397299
• ENSP00000380467
• ENSG00000243789

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.87
cellular component	0.82
cell type or tissue	0.74
tissue sample	0.68
tissue	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.07   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 88   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.07   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0