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Tchem
PLA2G4B
Cytosolic phospholipase A2 beta

Protein Summary
Description
Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine. Isoform 5 does have activity against phosphatidylcholine. This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic phospholipase A2 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000452633
  • ENSP00000396045
  • ENSG00000243708
  • ENST00000458483
  • ENSP00000416610

Symbol
  • HsT16992
  • cPLA2-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.72
histone modification site profile
0.72
tissue sample
0.69
tissue
0.54
cell line
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.9   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.9   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 26
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (42)
Acyl chain remodelling of PC (R-HSA-1482788)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Acyl chain remodelling of PG
Reactome
Acyl chain remodelling of PS
Reactome
Glycerophospholipid biosynthesis
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PG
Acyl chain remodelling of PS
Glycerophospholipid biosynthesis
Gene Ontology Terms (25)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (81)
1 – 10 of 81
GNAS
Tbio
Novelty: 0.00284739
Score: 0.83
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.83
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.83
Data Source: STRINGDB
PLA2G7
Tchem
Family: Enzyme
Novelty: 0.00270949
Score: 0.83
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.83
Data Source: STRINGDB
GNAQ
Tbio
Novelty: 0.0008997
Score: 0.83
Data Source: STRINGDB
PLD1
Tchem
Family: Enzyme
Novelty: 0.00608142
Score: 0.798
Data Source: STRINGDB
PLD2
Tchem
Family: Enzyme
Novelty: 0.00331129
Score: 0.795
Data Source: STRINGDB
PNPLA7
Tdark
Family: Enzyme
Novelty: 0.11025485
Score: 0.791
Data Source: STRINGDB
SELENOI
Tbio
Family: Enzyme
Novelty: 0.00809865
Score: 0.754
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.90

PubMed score by year
PubTator Score  6.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer