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Tdark
TBC1D3H
TBC1 domain family member 3H

Protein Summary
Description
Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610350
  • ENSP00000482630
  • ENSG00000274226
  • ENST00000619743
  • ENSP00000481632
  • ENSG00000277974
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.84
tissue sample
0.63
tissue
0.57
cell line
0.44
microRNA
0.41


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.04   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.04   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
64.9
1
1
0
1.1
64.9
macrophage inflammatory protein 1b measurement
1
1
1
47.4
macrophage inflammatory protein 1b measurement
1
1
1
47.4
CCL4 measurement
1
1
1
45.5
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
64.9
0
1.1
64.9
macrophage inflammatory protein 1b measurement
1
47.4
macrophage inflammatory protein 1b measurement
1
47.4
CCL4 measurement
1
45.5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P0C7X1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (9)
1 – 9 of 9
MYO19
Tbio
Novelty:  0.13070371
Score:  0.561
Data Source:  STRINGDB
TADA2A
Tbio
Family:  TF
Novelty:  0.07665459
Score:  0.537
Data Source:  STRINGDB
ZNHIT3
Tbio
Novelty:  0.08389205
Score:  0.535
Data Source:  STRINGDB
SYNRG
Tdark
Novelty:  0.03621564
Score:  0.529
Data Source:  STRINGDB
PIGW
Tbio
Novelty:  0.0245774
Score:  0.526
Data Source:  STRINGDB
ZNF670
Tdark
Family:  TF
Novelty:  1.79752674
Score:  0.523
Data Source:  STRINGDB
DUSP14
Tbio
Family:  Enzyme
Novelty:  0.04013065
Score:  0.497
Data Source:  STRINGDB
ZNF669
Tdark
Family:  TF
Novelty:  2.09725685
Score:  0.457
Data Source:  STRINGDB
C17orf78
Tdark
Novelty:  4.29271752
Score:  0.442
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.04

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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