Protein Summary
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity).
- ENST00000427980
- ENSP00000415822
- ENSG00000224470
- BOAT
- BOAT1
- BOAT
- BOAT1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.86 | ||
biological process | 0.68 | ||
cell type or tissue | 0.65 | ||
interacting protein | 0.6 | ||
transcription factor | 0.59 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.07 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 81 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.07 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 81 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
cigarettes per day measurement | 1 | 1 | 1 | 44.5 | |||||
reticulocyte count | 2 | 1 | 2 | 41 | |||||
reticulocyte measurement | 2 | 1 | 2 | 36.9 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
cigarettes per day measurement | 1 | 44.5 | |||||
reticulocyte count | 2 | 41 | |||||
reticulocyte measurement | 2 | 36.9 | |||||
Pathways (1)
KEGG (1)
Items per page:
1 – 1 of 1
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Notch signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Notch signaling pathway | ||||
Gene Ontology Terms (14)
Functions (2)
Components (4)
Processes (8)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (32)
1 – 10 of 32
CLASRP
Novelty: 0.00582947
p_int: 0.999999969
p_ni: 1.9e-8
p_wrong: 1.2e-8
Score: 0.233
Data Source: BioPlex,STRINGDB
ZBTB18
Family: TF
Novelty: 0.03802355
p_int: 0.999999923
p_ni: 5.5e-8
p_wrong: 2.2e-8
Score: 0.269
Data Source: BioPlex,STRINGDB
CIC
Family: TF
Novelty: 0.01006338
Score: 0.945
Data Source: STRINGDB
RBM17
Novelty: 0.04840999
Score: 0.767
Data Source: STRINGDB
ZNF821
Family: TF
Novelty: 0.48571429
Score: 0.742
Data Source: STRINGDB
BBX
Family: TF
Novelty: 0.02157387
Score: 0.734
Data Source: STRINGDB
TXNL4B
Novelty: 0.00695407
Score: 0.607
Data Source: STRINGDB
PCP2
Novelty: 0.05083955
Score: 0.601
Data Source: STRINGDB
PQBP1
Novelty: 0.01631148
Score: 0.579
Data Source: STRINGDB
HBP1
Family: TF
Novelty: 0.06312067
Score: 0.576
Data Source: STRINGDB
Publication Statistics
PubMed Score 10.07
PubMed score by year
PubTator Score 116.38
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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