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Tbio
ATXN1L
Ataxin-1-like

Protein Summary
Description
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000427980
  • ENSP00000415822
  • ENSG00000224470

Symbol
  • BOAT
  • BOAT1
  • BOAT
  • BOAT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
biological process
0.68
cell type or tissue
0.65
interacting protein
0.6
transcription factor
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.07   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.07   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cigarettes per day measurement
1
1
1
44.5
reticulocyte count
2
1
2
41
reticulocyte measurement
2
1
2
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cigarettes per day measurement
1
44.5
reticulocyte count
2
41
reticulocyte measurement
2
36.9
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (32)
1 – 10 of 32
CLASRP
Tbio
Novelty: 0.00582947
p_int: 0.999999969
p_ni: 1.9e-8
p_wrong: 1.2e-8
Score: 0.233
Data Source: BioPlex,STRINGDB
ZBTB18
Tbio
Family: TF
Novelty: 0.03802355
p_int: 0.999999923
p_ni: 5.5e-8
p_wrong: 2.2e-8
Score: 0.269
Data Source: BioPlex,STRINGDB
CIC
Tbio
Family: TF
Novelty: 0.01006338
Score: 0.945
Data Source: STRINGDB
RBM17
Tbio
Novelty: 0.04840999
Score: 0.767
Data Source: STRINGDB
ZNF821
Tdark
Family: TF
Novelty: 0.48571429
Score: 0.742
Data Source: STRINGDB
BBX
Tbio
Family: TF
Novelty: 0.02157387
Score: 0.734
Data Source: STRINGDB
TXNL4B
Tbio
Novelty: 0.00695407
Score: 0.607
Data Source: STRINGDB
PCP2
Tdark
Novelty: 0.05083955
Score: 0.601
Data Source: STRINGDB
PQBP1
Tbio
Novelty: 0.01631148
Score: 0.579
Data Source: STRINGDB
HBP1
Tbio
Family: TF
Novelty: 0.06312067
Score: 0.576
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.07

PubMed score by year
PubTator Score  116.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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