Tbio ATXN1L Ataxin-1-like

Protein Summary

Description

Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity).

Uniprot Accession IDs

• P0C7T5

Gene Name

• ATXN1L

Ensembl ID

• ENST00000427980
• ENSP00000415822
• ENSG00000224470

Symbol

• BOAT
• BOAT1
• BOAT
• BOAT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.86
biological process	0.68
cell type or tissue	0.65
interacting protein	0.6
transcription factor	0.59

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.86   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 81   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.86   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (1)

KEGG (1)

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Notch signaling pathway	53 targets	path:hsa04330

Name	Explore in Pharos	Explore in Source
Notch signaling pathway	53 targets	path:hsa04330

Gene Ontology Terms (14)

Functions (2)

Components (4)

Processes (8)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
RNA binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (32)

Explore Interacting Targets

1 – 10 of 32

• See Interactions on String-DB

CLASRP

Tbio

Novelty: 0.00099222

p_int: 0.999999969

p_ni: 1.9e-8

p_wrong: 1.2e-8

Score: 0.233

Data Source: BioPlex,STRINGDB

ZBTB18

Tbio

Family: TF

Novelty: 0.06172849

p_int: 0.999999923

p_ni: 5.5e-8

p_wrong: 2.2e-8

Score: 0.269

Data Source: BioPlex,STRINGDB

CIC

Tbio

Family: TF

Novelty: 0.01217744

Score: 0.945

Data Source: STRINGDB

RBM17

Tbio

Novelty: 0.05783133

Score: 0.767

Data Source: STRINGDB

ZNF821

Tdark

Family: TF

Novelty: 0.83333333

Score: 0.742

Data Source: STRINGDB

BBX

Tbio

Family: TF

Novelty: 0.02256768

Score: 0.734

Data Source: STRINGDB

TXNL4B

Tbio

Novelty: 0.00158517

Score: 0.607

Data Source: STRINGDB

PCP2

Tdark

Novelty: 0.06252326

Score: 0.601

Data Source: STRINGDB

PQBP1

Tbio

Novelty: 0.0195288

Score: 0.579

Data Source: STRINGDB

HBP1

Tbio

Family: TF

Novelty: 0.07252633

Score: 0.576

Data Source: STRINGDB

Publication Statistics

PubMed Score  11.86

PubMed score by year

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PubTator Score  116.38

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MKPVHERSQECLPPKKRDLPVTSEDMGRTTSCSTNHTPSSDASEWSRGVVVAGQSQAGARVSLGGDGAEA

1-70

ITGLTVDQYGMLYKVAVPPATFSPTGLPSVVNMSPLPPTFNVASSLIQHPGIHYPPLHYAQLPSTSLQFI

70-140

GSPYSLPYAVPPNFLPSPLLSPSANLATSHLPHFVPYASLLAEGATPPPQAPSPAHSFNKAPSATSPSGQ

140-210

LPHHSSTQPLDLAPGRMPIYYQMSRLPAGYTLHETPPAGASPVLTPQESQSALEAAAANGGQRPRERNLV

210-280

RRESEALDSPNSKGEGQGLVPVVECVVDGQLFSGSQTPRVEVAAPAHRGTPDTDLEVQRVVGALASQDYR

280-350

VVAAQRKEEPSPLNLSHHTPDHQGEGRGSARNPAELAEKSQARGFYPQSHQEPVKHRPLPKAMVVANGNL

350-420

VPTGTDSGLLPVGSEILVASSLDVQARATFPDKEPTPPPITSSHLPSHFMKGAIIQLATGELKRVEDLQT

420-490

QDFVRSAEVSGGLKIDSSTVVDIQESQWPGFVMLHFVVGEQQSKVSIEVPPEHPFFVYGQGWSSCSPGRT

490-560

TQLFSLPCHRLQVGDVCISISLQSLNSNSVSQASCAPPSQLGPPRERPERTVLGSRELCDSEGKSQPAGE

560-630

GSRVVEPSQPESGAQACWPAPSFQRYSMQGEEARAALLRPSFIPQEVKLSIEGRSNAGK

630-689

MKPVHERSQECLPPKKRDLPVTSEDMGRTTSCSTNHTPSSDASEWSRGVVVAGQSQAGARVSLGGDGAEAITGLTVDQYGMLYKVAVPPATFSPTGLPSVVNMSPLPPTFNVASSLIQHPGIHYPPLHYAQLPSTSLQFIGSPYSLPYAVPPNFLPSPLLSPSANLATSHLPHFVPYASLLAEGATPPPQAPSPAHSFNKAPSATSPSGQLPHHSSTQPLDLAPGRMPIYYQMSRLPAGYTLHETPPAGASPVLTPQESQSALEAAAANGGQRPRERNLVRRESEALDSPNSKGEGQGLVPVVECVVDGQLFSGSQTPRVEVAAPAHRGTPDTDLEVQRVVGALASQDYRVVAAQRKEEPSPLNLSHHTPDHQGEGRGSARNPAELAEKSQARGFYPQSHQEPVKHRPLPKAMVVANGNLVPTGTDSGLLPVGSEILVASSLDVQARATFPDKEPTPPPITSSHLPSHFMKGAIIQLATGELKRVEDLQTQDFVRSAEVSGGLKIDSSTVVDIQESQWPGFVMLHFVVGEQQSKVSIEVPPEHPFFVYGQGWSSCSPGRTTQLFSLPCHRLQVGDVCISISLQSLNSNSVSQASCAPPSQLGPPRERPERTVLGSRELCDSEGKSQPAGEGSRVVEPSQPESGAQACWPAPSFQRYSMQGEEARAALLRPSFIPQEVKLSIEGRSNAGK

Find similar targets by:

Uniprot Keyword

Cell projection
Complete proteome
DNA-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repressor
Transcription
Transcription regulation